Topic: Biologics and Antibody Disposition in PBPK

Worked Construction of an IgG Tissue-Distribution Model

Whole-Body FcRn Effects on Antibody Clearance

Transcapillary IgG Exchange and Vascular Reflection

Predicting Disposition Changes Across IgG Formats

pH-Dependent FcRn Binding in Endosomes

Interstitial Convection and Lymphatic Antibody Return

Diagnosing Antibody Tissue-Distribution Parameters

Deriving a Lymph-Draining Tissue Model

Deriving FcRn Salvage and Recycling Fluxes

Common Structural Errors in Antibody Disposition Models