Topic: Decision Analysis for Development Programs

Valuing Biomarker and Dose-Finding Studies

Value of Information Under Model Uncertainty

Value of Perfect Information

Timing, Delay, and Cost in Information Value

Stage-Gate Policies as Sequential Decisions

Staged Investment and the Value of Retaining Options

Risk-Adjusted NPV with Technical Success

Robust Go Or No-Go Decisions Under Probability Uncertainty

Predictive Probability of Trial Success

Predictive-Probability Rules for Interim Decisions