Accelerated Titration Designs
A computational guide to accelerated titration designs for Phase I oncology trials, including rapid dose escalation, intrapatient dose escalation, dose-limiting toxicity, moderate toxicity, transition to conventional escalation, dose-toxicity modeling, and a complete worked example.
3+3 Design Explained
A comprehensive guide to the traditional 3+3 dose-escalation design for Phase I clinical trials, including dose cohorts, dose-limiting toxicities, escalation rules, expansion to six patients, MTD determination, worked examples, operating characteristics, limitations, and alternatives.