Topic: Dose Justification Across Development Phases

Identifying the Therapeutic Window From Dose-Response Evidence

Evaluating Nonmonotonic Dose-Response for Dose Selection

Estimating Posterior Probabilities of Dose Targets

Establishing a Minimum Effective Dose

Distinguishing Plateau Dose From Maximum Tested Dose

Diagnosing Dose-Response Model Misspecification

Diagnosing Heterogeneity in Pooled Dose-Response Evidence

Defining Dose-Response Estimands Across Development Phases

Confirming the Selected Dose in Phase 3

Choosing Dose-Response Models for Dose Justification