Topic: Dose Selection by Simulation

Worked PTA Dose Selection for AUC/MIC

Worked Comparison of Competing Regimens

Worked Dose Selection for Time Above MIC

Weight-Based Versus Fixed Dosing

Time-Above-Target PTA for Concentration Profiles

Translating Exposure-Response Evidence Into Targets

Steady-State Versus First-Dose Target Attainment

Simulating Dose and Regimen Candidates

Selecting Doses Under Parameter Uncertainty

Sensitivity of Dose Recommendations to PK/PD Assumptions