Topic: Enzyme Inhibition and Induction

Worked Case: Reversible Inhibition During Repeated Dosing

Worked Case: Time-Dependent Inhibition and Recovery

Worked Equilibrium Inhibition in a Hepatic PBPK Model

Worked Case: Delayed Induction and Washout

Unbound Inhibitor Concentrations at the Enzyme Site

Time-Varying Inhibitor and Inducer Exposure

Receptor-Mediated Enzyme Induction

Onset and Offset of Enzyme Induction

Mechanism-Based Enzyme Inactivation

Mechanistic Classes of Enzyme Inhibition