Mechanism-Based PK/PD Models
Learn how mechanism-based PK/PD models connect drug concentration to biological processes such as target binding, signaling, biomarker turnover, pharmacologic effect, and feedback.
Mechanism-Based Inhibition Models
A practical introduction to mechanism-based inhibition models, including reversible and irreversible enzyme inhibition, time-dependent inhibition, inactivation kinetics, and how MBI models are used in pharmacokinetic drug-drug interaction assessment.
Mechanism-Based Activation Models
Learn how mechanism-based activation models describe the conversion of inactive compounds or precursors into active species, including prodrug activation, metabolite formation, enzyme-mediated activation, active-site processes, and PK/PD applications.
Maximum Effect and EC50 Estimation
Learn how maximum effect and EC50 are estimated from concentration-response data using Emax models, including model fitting, interpretation, worked examples, uncertainty, and common pitfalls.
Longitudinal Exposure-Response Models
Learn how longitudinal exposure-response models connect time-varying drug exposure with repeated efficacy or safety outcomes, including dynamic exposure metrics, repeated-measures models, nonlinear exposure-response relationships, and model-based prediction.
Link Models for Delayed Pharmacodynamic Effects
Learn how link models connect pharmacokinetic concentration to delayed pharmacodynamic effects, including effect-compartment models, hysteresis, turnover models, and indirect-response approaches.
Linear PK/PD Models
Learn how linear PK/PD models connect drug concentration or exposure to pharmacodynamic response, including direct-effect models, baseline effects, slope models, linear exposure-response relationships, assumptions, worked examples, and model interpretation.
Joint PK/PD Modeling of Multiple Endpoints
Learn how joint PK/PD models describe multiple pharmacodynamic endpoints simultaneously, share pharmacokinetic exposure, account for endpoint-specific dynamics and variability, and support integrated exposure-response prediction.
Introduction to PK/PD Modeling: Linking Exposure to Effect
An introduction to pharmacokinetic-pharmacodynamic modeling, showing how PK models describe drug exposure and PD models connect concentration or exposure to pharmacologic effect, including direct-effect, indirect-effect, Emax, sigmoid Emax, and effect-compartment models.
Inhibitory Emax Models
Learn how inhibitory Emax models describe concentration-dependent reductions in pharmacologic effect, including Imax, IC50, baseline effect, model assumptions, parameter interpretation, worked examples, and PK/PD applications.