Topic: Genetic Polymorphisms and Virtual Populations

Translating Diplotypes Into Enzyme Activity

Stratified Virtual Populations by Genotype

Sourcing Allele Frequencies for PBPK Cohorts

Representing Pharmacogenetic Transporter Variation

Sampling Continuous Physiological Variability

Sampling Discrete Genotypes for Virtual Subjects

Rare Alleles and Uncertain Functional Effects

Preserving Dependence Among Virtual-Subject Covariates

Phenoconversion and Genotype-Based Phenotypes

Interpreting Population Differences in Allele Frequencies