Topic: Hepatic Clearance Models

Low-Extraction Limits Across the Three Models

Interpreting the Dispersion Number and Its Limits

Intrinsic-Clearance Sensitivity Across Liver Models

Hepatic Availability From First-Pass Extraction

Hepatic Clearance From Inlet and Outlet Concentrations

High-Extraction Limits Across the Three Models

Identifiability of Flow and Intrinsic Clearance

Flow Sensitivity in the Three Liver Models

Extraction Ratio as a Comparison Scale

Discriminating Liver Models With Flow Perturbation Data