Target-Mediated Drug Disposition in Monoclonal Antibodies
Learn how target-mediated drug disposition (TMDD) produces nonlinear pharmacokinetics of monoclonal antibodies through target binding, receptor turnover, internalization, and saturable elimination.
Target-Mediated Drug Disposition Models
Learn how target-mediated drug disposition models describe nonlinear pharmacokinetics caused by binding to a pharmacologic target, including receptor binding, internalization, degradation, TMDD mechanisms, model parameters, and worked examples.
Systems Pharmacology of Monoclonal Antibodies
Learn how systems pharmacology describes monoclonal antibodies by integrating PK, FcRn recycling, target binding, target-mediated drug disposition, pharmacodynamics, target engagement, and mechanistic biological pathways.
Intracellular Drug Concentration Models
Learn how intracellular drug concentration models describe drug distribution between plasma, extracellular fluid, and intracellular compartments, including passive diffusion, active transport, binding, and intracellular exposure.
FcRn-Mediated Disposition Models
Learn how FcRn-mediated recycling influences IgG and therapeutic antibody disposition, how FcRn models represent saturable salvage and degradation, and how mechanistic FcRn PK models support biologic drug development.
Drug Distribution into Tumors
Learn how drugs distribute into tumors, how perfusion, permeability, interstitial transport, binding, cellular uptake, and tumor heterogeneity influence tumor exposure, and how PK models quantify tumor drug distribution.
Antibody Distribution and Tissue Penetration
Learn how monoclonal antibodies distribute from plasma into tissues, how vascular permeability, convection, diffusion, FcRn, target binding, and tissue physiology influence penetration, and how mechanistic PK models describe antibody distribution.