Topic: Mixture and Latent Subpopulation Models

Worked Analysis of Fast and Slow Clearance Subgroups

When a Latent Metabolizer Class Is Needed

Testing for a Second Metabolizer Class

The Two-Class NLME Likelihood

Simulation Checks for Mixture Models

Stable Initialization for Two-Class NLME Fits

Sharing Parameters Across Metabolizer Classes

Reporting and Predicting With Metabolizer Mixtures

Parameterizing Fast and Slow Clearance Classes

Latent Classes Versus Observed Metabolizer Phenotypes