Topic: Nonlinear Elimination and Time-Varying Clearance

Worked Analysis of Autoinduction Data

Turnover Models for Enzyme Abundance

Testing Saturable Against Linear Elimination

The Michaelis-Menten Elimination Rate Law

Steady-State Concentrations During Constant-Rate Infusion

Separating Saturable Elimination From Time-Dependent Clearance

Residual Error Choices for Saturable Concentration Profiles

Random Effects on Induction Parameters

Random Effects on Vmax and Km

Profile Likelihood for Vmax and Km