Topic: Numerical Implementation and Stiff Solvers

Troubleshooting Failed PBPK Integrations

Using Jacobians and Sparsity in Stiff Integration

Testing Solver Convergence and Numerical Error

Setting Solver Tolerances for Unequal State Scales

Scheduling Repeated Doses Across Solver Discontinuities

Representing Bolus Doses as Discrete State Jumps

Modeling Infusions with Start and Stop Events

Implementing Blood-Flow Coupling in the Derivative Function

Explicit and Implicit Solvers for PBPK Systems

Extracting Predictions at Observation Times