Sex and Pharmacokinetics
Learn how biological sex can influence pharmacokinetics through differences in absorption, distribution, metabolism, and elimination, and how sex can be incorporated into PK analysis, population PK models, and clinical pharmacology studies.
Model-Informed Renal Impairment Dosing
Learn how population PK, PBPK, renal function relationships, exposure-response models, and dialysis considerations can be integrated to develop model-informed dosing recommendations for patients with renal impairment.
Model-Informed Pediatric Drug Development
Learn how model-informed drug development uses pharmacokinetic, pharmacodynamic, population PK, PBPK, exposure-response, and simulation methods to support pediatric dose selection, extrapolation, trial design, and regulatory decision-making.
Model-Informed Hepatic Impairment Dosing
Learn how pharmacokinetic, population PK, and physiologically based pharmacokinetic models can be used to understand hepatic impairment, predict changes in drug exposure, and inform dose selection.
Age and Pharmacokinetics
Learn how age can influence pharmacokinetics through changes in clearance, volume of distribution, absorption, organ function, body composition, and population PK covariates.