Topic: Renal Elimination and Renal Transporters

Verifying Renal PBPK Models With Plasma and Urine Data

Tubular Secretion as a Two-Membrane Flux

Unbound Drug Filtration Across the Glomerulus

Unbound Inhibitor Exposure at Renal Transporters

Urine Flow, Transit, and Reabsorption

Vectorial Transport Across Renal Cell Membranes

Scaling Renal Transporter Abundance and Activity

Saturable Secretion and Dose-Dependent Renal Clearance

Renal Drug Mass Balance From Plasma to Urine

Proximal Tubule Cell Compartments and Transport Direction