Topic: Small Molecules in Mechanistic Models

Worked Integration From Dose to Pathway Biomarker

Unbound Drug Concentration at the Intracellular Target

Translating Biochemical Potency Into Cellular Target Inhibition

Target Reserve Between Inhibition and Functional Response

Propagating Target Inhibition to a Pathway Biomarker

Noncompetitive and Mixed Inhibition in Pathway Models

Irreversible Inhibition and Target Resynthesis

Effect-Site Equilibration for Small-Molecule Targets

Diagnosing Hysteresis Between Exposure and Pathway Response

Deriving Fractional Inhibition From Unbound Concentration