Topic: Target-Mediated Drug Disposition and PK/PD

Sampling Designs That Separate TMDD Processes

Quasi-Steady-State Reduction of the Full TMDD Model

Rapid-Equilibrium and Michaelis-Menten Approximations

Repeated Dosing and Target Recovery

Observation Models for Drug-Target Complex Assays

Modeling Pharmacology of Soluble-Target Neutralization

Linking Target Occupancy to Pharmacodynamic Response

Infusion Dose-Exposure Relationships Under TMDD

How Target Abundance Changes Nonlinear Drug Exposure

Identifiability of Binding, Internalization, and Target Turnover