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Topic:
Target-Mediated Drug Disposition in NLME
Mass-Action TMDD State Equations
Likelihoods for Free, Total, and Target Measurements
Identifiability of Binding and Target-Turnover Parameters
Deriving the Quasi-Steady-State Approximation
Diagnosing Approximation Failure Across Dose and Time
Choosing Full TMDD, QSS, or Michaelis-Menten Models
Baseline Target Equilibrium and TMDD Initial Conditions
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