Topic: The Marginal Likelihood and Its Approximations

Diagnostic Patterns of Approximation Bias

Constructing the FO Subject Likelihood

Conditional Likelihood and Random-Effect Modes

Conditional Linearization in FOCE

Conditional Modes in FOCE

Choosing an Approximation for a Given NLME Likelihood

Building the FOCE Approximate Likelihood

Asymmetric Curvature and Laplace Error

Approximation Behavior With Rich Within-Subject Data

Approximation Bias in Sparse Sampling Designs