Topic: Time-to-Event MAMS With Intermediate Outcomes

Worked Example With a Biomarker and Event Endpoint

Worked Example With Early Response and Overall Survival

Worked Example With Progression-Free Survival Selection

Translating Intermediate Contrasts Into Final-Endpoint Predictions

Treatment-Effect Heterogeneity in Intermediate Outcomes

Treatment-Effect Surrogacy Across Arms

Validating a Simulation of Delayed Outcomes

Surrogacy Claims for Selection Outcomes

The Surrogate Paradox in Arm Selection

Threshold Rules for Retaining Arms