Topic: Time Trends and Drift

Worked Example: Worsening Prognosis During Adaptive Enrollment

Worked Design Example With Midtrial Calendar-Time Blocks

Worked Example: Improving Prognosis Mimics Treatment Benefit

What Concurrent Controls Do and Do Not Guarantee

When Recorded Enrollment Time Is Not Enough

Time-Stratified Treatment Effect Standardization

Treatment Effects That Change Over Calendar Time

Uncertainty Estimates After Calendar-Time Adjustment

Temporal Blocking to Balance Enrollment Periods

Smoothing Allocation Updates to Limit Abrupt Time Shifts