Topic: Tolerance, Rebound and Adaptation

Worked Analysis of Repeated-Dose Tolerance

Time-Varying Receptor Desensitization Models

State-Variable Models of Pharmacodynamic Tolerance

Sensitization and Paradoxical Adaptation

Separating Pharmacokinetic From Pharmacodynamic Tolerance

Quantifying Tolerance as Potency or Efficacy Change

Rebound Versus Return of the Untreated Disease

Receptor Internalization and Recycling During Tolerance

Population Variability in Tolerance Development

Operational Definitions of Tolerance and Rebound