Topic: Two-Sided and Asymmetric Designs

Worked Example Of Symmetric Two-Sided Monitoring

Worked Example Of Unequal Clinical Crossing Limits

Worked Example Of Unequal Tail Error Budgets

Why Per-Tail Alpha Does Not Ignore Cross-Look Dependence

When Symmetric Boundaries Lose Directional Power

Unequal Directional Error Budgets

Unequal Upper And Lower Efficacy Limits

Two-Sided Group Sequential Decision Regions

Tail Allocation Versus Boundary Shape

Stopping Rules With Separate Efficacy Limits