Topic: Unblinded Re-Estimation and the Promising Zone

Writing an Executable Re-Estimation Rule

Z-Statistic-Based Sample Size Adaptation

Worked Normal-Endpoint Conditional-Power Calculation

Worked Promising-Zone Rule Calculation

When the Maximum Sample Size Binds

Unequal Allocation in Promising-Zone Re-Estimation

Unblinded Sample Size Re-Estimation as an Adaptive Design

Target Conditional Power and Target Final Power

Selecting Promising-Zone Conditional-Power Cutoffs

Sensitivity Analysis Across True Treatment Effects