Topic: What QSP Is and When It Helps

When More Mechanistic Detail Does Not Improve a Decision

When QSP Adds Value to a Development Decision

Translating Mechanisms Across Species and Experimental Systems

Target Selection as a QSP Decision Case

Recognizing Unsupported Links in Mechanistic Extrapolation

Mechanistic States, Observables, and Clinical Endpoints

Integrating Evidence Across Assays and Biological Scales

Evidence Chains From Drug Action to Clinical Outcome

Extrapolating Across Dose Levels and Schedules

Distinguishing Competing Biological Explanations