Topic: Worked Case Studies

Linking Receptor Occupancy to Tumor Response

From Phase II Data to a Regimen Recommendation

Estimating a Drug Interaction From Paired PK/PD Data

Evaluating a Biomarker as a Surrogate in a Treatment Case

Exposure-Linked Time to Disease Progression

Distinguishing Target-Mediated Disposition in a Monoclonal Antibody Case

Diagnosing PD Model Misspecification From Residual Patterns

Detecting Tolerance During Repeated Opioid Dosing

Comparing Sequential and Simultaneous Estimation in One Study

An Indirect-Response Case for Antihypertensive Biomarkers