Trials that use: Interim analysis / alpha spending
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4,594 results
- A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Participants With Giant Cell Arteritis (GCA).: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Participants With Giant Cell Arteritis (GCA).: primary endpoint results, effect estimate with confidence interval,…
- A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of PF-06882961 in Chinese Adults With Type 2 Diabetes Mellitus: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of PF-06882961 in Chinese Adults With Type 2 Diabetes Mellitus: primary endpoint results, effect estimate with confidence interval,…
- A Study to Evaluate the Product Feasibility of a New Silicone Hydrogel Contact Lens: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Product Feasibility of a New Silicone Hydrogel Contact Lens: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- A Study to Evaluate the Safe and Effective Use of a Zilucoplan Auto-injector by Study Participants With Generalized Myasthenia Gravis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safe and Effective Use of a Zilucoplan Auto-injector by Study Participants With Generalized Myasthenia Gravis: primary endpoint results, effect estimate with confidence interval,…
- A Study to Evaluate the Safety and Effectiveness of a Contact Lens Cleaning and Disinfecting Solution: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Effectiveness of a Contact Lens Cleaning and Disinfecting Solution: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Evaluate the Safety and Effectiveness of Ustekinumab or Golimumab Administered Subcutaneously (SC) in Patients With Sarcoidosis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Effectiveness of Ustekinumab or Golimumab Administered Subcutaneously (SC) in Patients With Sarcoidosis: primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Evaluate the Safety and Efficacy of AVTX-002 for the Treatment of Poorly Controlled Non-Eosinophilic Asthma.: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Efficacy of AVTX-002 for the Treatment of Poorly Controlled Non-Eosinophilic Asthma.: primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Evaluate the Safety and Efficacy of Denosumab and Ibandronate in Postmenopausal Women Sub-Optimally Treated With Daily or Weekly Bisphosphonates: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Efficacy of Denosumab and Ibandronate in Postmenopausal Women Sub-Optimally Treated With Daily or Weekly Bisphosphonates: primary endpoint results, effect estimate with…
- A Study to Evaluate the Safety and Efficacy of Ruxolitinib Phosphate Cream Applied Topically to Adults With Atopic Dermatitis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Efficacy of Ruxolitinib Phosphate Cream Applied Topically to Adults With Atopic Dermatitis: primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Evaluate the Safety and Efficacy of Satralizumab in Participants With Neuromyelitis Optica Spectrum Disorder (NMOSD): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Efficacy of Satralizumab in Participants With Neuromyelitis Optica Spectrum Disorder (NMOSD): primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Evaluate the Safety and Efficacy of TS-121 as an Adjunctive Treatment for Major Depressive Disorder: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Efficacy of TS-121 as an Adjunctive Treatment for Major Depressive Disorder: primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Evaluate the Safety and Efficacy of Ustekinumab Maintenance Therapy in Patients With Moderately to Severely Active Crohn’s Disease (IM-UNITI): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Efficacy of Ustekinumab Maintenance Therapy in Patients With Moderately to Severely Active Crohn's Disease (IM-UNITI): primary endpoint results, effect estimate with…
- A Study to Evaluate the Safety and Immunogenicity for Regimen Selection of Ad26.RSV.preF and/or RSV preF Protein Combinations Followed by Expanded Safety Evaluation in Adults Aged 60 Years and Older: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Immunogenicity for Regimen Selection of Ad26.RSV.preF and/or RSV preF Protein Combinations Followed by Expanded Safety Evaluation in Adults Aged 60 Years…
- A Study to Evaluate the Safety and Immunogenicity of Inactivated Varicella Zoster Virus (VZV) Vaccine in Adults With Autoimmune Disease (V212-009): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Immunogenicity of Inactivated Varicella Zoster Virus (VZV) Vaccine in Adults With Autoimmune Disease (V212-009): primary endpoint results, effect estimate with confidence…
- A Study to Evaluate the Safety and Immunogenicity of V710 in Adults With Kidney Disease on Hemodialysis (V710-005)(COMPLETED): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Immunogenicity of V710 in Adults With Kidney Disease on Hemodialysis (V710-005)(COMPLETED): primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Evaluate the Safety and Tolerability of RO7296682 in Participants With Advanced Solid Tumors: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Tolerability of RO7296682 in Participants With Advanced Solid Tumors: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Evaluate the Safety of Aceneuramic Acid Extended Release (Ace-ER; UX001) Tablets in Glucosamine (UDP-N-acetyl)-2-Epimerase (GNE) Myopathy (GNEM) (Also Known as Hereditary Inclusion Body Myopathy [HIBM]) Patients With Severe Ambulatory Impairment: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety of Aceneuramic Acid Extended Release (Ace-ER; UX001) Tablets in Glucosamine (UDP-N-acetyl)-2-Epimerase (GNE) Myopathy (GNEM) (Also Known as Hereditary Inclusion Body Myopathy [HIBM])…
- A Study to Evaluate the Safety of Combination Montelukast/Loratadine in Mexican Participants With Allergic Rhinitis (MK-0476A-484): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety of Combination Montelukast/Loratadine in Mexican Participants With Allergic Rhinitis (MK-0476A-484): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Evaluate the Safety, PK, PD, Immunogenicity of N-Rephasin® SAL200 in Healthy Male Volunteers: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, PK, PD, Immunogenicity of N-Rephasin® SAL200 in Healthy Male Volunteers: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RO7062931 in Healthy Chinese Volunteers.: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RO7062931 in Healthy Chinese Volunteers.: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…
- A Study to Evaluate the Safety, Tolerability, and Antitumor Activity of INCB001158 Plus Epacadostat, With or Without Pembrolizumab, in Advanced Solid Tumors: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, Tolerability, and Antitumor Activity of INCB001158 Plus Epacadostat, With or Without Pembrolizumab, in Advanced Solid Tumors: primary endpoint results, effect estimate with…
- A Study to Evaluate the Safety, Tolerability, and Efficacy of the Addition of Omarigliptin (MK-3102) to Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin Therapy (MK-3102-024): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, Tolerability, and Efficacy of the Addition of Omarigliptin (MK-3102) to Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on…
- A Study to Evaluate the Safety, Tolerability, and Immunogenicity of the rSm-p80 + GLA-SE (SchistoShield®) Candidate Vaccine in Healthy Adults in Burkina Faso and Madagascar: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, Tolerability, and Immunogenicity of the rSm-p80 + GLA-SE (SchistoShield®) Candidate Vaccine in Healthy Adults in Burkina Faso and Madagascar: primary endpoint results,…
- A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Two Lots of V114 in Healthy Infants (V114-008): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Two Lots of V114 in Healthy Infants (V114-008): primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Inhaled Montelukast (MK-0476) in Participants With Mild or Moderate Asthma (MK-0476-380 AM3)(COMPLETED): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Inhaled Montelukast (MK-0476) in Participants With Mild or Moderate Asthma (MK-0476-380 AM3)(COMPLETED): primary endpoint results, effect estimate with…
- A Study to Evaluate the Safety, Tolerability, and Weight Loss Efficacy of K-757 Alone and in Combination With K-833: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, Tolerability, and Weight Loss Efficacy of K-757 Alone and in Combination With K-833: primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Co-Administration of Roluperidone and Olanzapine in Adult Subjects With Moderate to Severe Negative Symptoms of Schizophrenia: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Co-Administration of Roluperidone and Olanzapine in Adult Subjects With Moderate to Severe Negative Symptoms of Schizophrenia: primary…
- A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06882961 in Japanese Adults With Type 2 Diabetes Mellitus: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06882961 in Japanese Adults With Type 2 Diabetes Mellitus: primary endpoint results, effect estimate with confidence interval,…
- A Study to Evaluate the Usability of the SB11 PFS in Subjects With Wet AMD or Macular Oedema Secondary to RVO: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Usability of the SB11 PFS in Subjects With Wet AMD or Macular Oedema Secondary to RVO: primary endpoint results, effect estimate with confidence…
- A Study to Evaluate the Use and Safety of CARDIOLITE® in Pediatric Patients With Kawasaki Disease: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Use and Safety of CARDIOLITE® in Pediatric Patients With Kawasaki Disease: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF): Complete Statistical AnalysisIndependent statistical analysis of A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF): primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Find the Dose and Assess the Immune Response and Safety of a Vaccine Against Influenza in Healthy Younger and Older Adults: Complete Statistical AnalysisIndependent statistical analysis of A Study to Find the Dose and Assess the Immune Response and Safety of a Vaccine Against Influenza in Healthy Younger and Older Adults: primary endpoint results, effect…
- A Study To Investigate And Describe The Treatment Patterns And Effect Of Tofacitinib Indicators For Patients With Rheumatoid Arthritis: Complete Statistical AnalysisIndependent statistical analysis of A Study To Investigate And Describe The Treatment Patterns And Effect Of Tofacitinib Indicators For Patients With Rheumatoid Arthritis: primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Investigate Sitravatinib as Monotherapy and in Combination With Tislelizumab in Participants With Unresectable Locally Advanced or Metastatic Hepatocellular Carcinoma or Gastric/Gastroesophageal Junction Cancer: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate Sitravatinib as Monotherapy and in Combination With Tislelizumab in Participants With Unresectable Locally Advanced or Metastatic Hepatocellular Carcinoma or Gastric/Gastroesophageal Junction Cancer: primary endpoint…
- A Study to Investigate the Analgesic Efficacy of AZD2423 Compared With Placebo After 28 Days Treatment in Patients With Painful Diabetic Polyneuropathy: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Analgesic Efficacy of AZD2423 Compared With Placebo After 28 Days Treatment in Patients With Painful Diabetic Polyneuropathy: primary endpoint results, effect estimate with…
- A Study to Investigate the Efficacy and Safety of Balovaptan (RO5285119) in Participants With Autism Spectrum Disorder (ASD): Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Efficacy and Safety of Balovaptan (RO5285119) in Participants With Autism Spectrum Disorder (ASD): primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Investigate the Efficacy and Safety of Two Doses of GSK2857916 in Participants With Multiple Myeloma Who Have Failed Prior Treatment With an Anti-CD38 Antibody: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Efficacy and Safety of Two Doses of GSK2857916 in Participants With Multiple Myeloma Who Have Failed Prior Treatment With an Anti-CD38 Antibody: primary…
- A Study to Investigate the Efficacy, Safety and Tolerability of Four Different Doses of BI 409306 Compared to Placebo Given for 12 Weeks in Patients With Schizophrenia on Stable Antipsychotic Treatment.: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Efficacy, Safety and Tolerability of Four Different Doses of BI 409306 Compared to Placebo Given for 12 Weeks in Patients With Schizophrenia on…
- A Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis: primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Investigate the Pharmacokinetics of a Combined Oral Contraceptive When Given Alone and in Combination With GSK3036656 in Female Participants of Non-childbearing Potential Aged 18 to 65 Years of Age: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Pharmacokinetics of a Combined Oral Contraceptive When Given Alone and in Combination With GSK3036656 in Female Participants of Non-childbearing Potential Aged 18 to…
- A Study to Investigate the Pharmacokinetics, Efficacy and Safety of INM005 in Patients With COVID-19.: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Pharmacokinetics, Efficacy and Safety of INM005 in Patients With COVID-19.: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…
- A Study To Investigate The Pharmacokinetics, Safety And Tolerability Of An Intravenous And Oral Form Of A Compound In Subjects With Varying Degrees Of Renal Impairment And Normal Renal Function: Complete Statistical AnalysisIndependent statistical analysis of A Study To Investigate The Pharmacokinetics, Safety And Tolerability Of An Intravenous And Oral Form Of A Compound In Subjects With Varying Degrees Of Renal Impairment And Normal…
- A Study To Investigate The Safety And Efficacy Of CP- 690,550 In Patients With Moderate And Severe Ulcerative Colitis.: Complete Statistical AnalysisIndependent statistical analysis of A Study To Investigate The Safety And Efficacy Of CP- 690,550 In Patients With Moderate And Severe Ulcerative Colitis.: primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Investigate the Safety and Efficacy of CP-690,550 in Patients With Moderate to Severe Crohn’s Disease: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Safety and Efficacy of CP-690,550 in Patients With Moderate to Severe Crohn's Disease: primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK2816126 in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma, Transformed Follicular Lymphoma, Other Non-Hodgkin’s Lymphomas, Solid Tumors and Multiple Myeloma: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK2816126 in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma, Transformed Follicular Lymphoma, Other Non-Hodgkin's Lymphomas,…
- A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Learn About New COVD-19 RNA Vaccine Candidates for New Variants in Healthy Individuals: Complete Statistical AnalysisIndependent statistical analysis of A Study to Learn About New COVD-19 RNA Vaccine Candidates for New Variants in Healthy Individuals: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Learn About Novel Hormonal Therapies in People With Metastatic Castration-Sensitive Prostate Cancer (mCSPC): Complete Statistical AnalysisIndependent statistical analysis of A Study to Learn About Novel Hormonal Therapies in People With Metastatic Castration-Sensitive Prostate Cancer (mCSPC): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich’s Ataxia: Complete Statistical AnalysisIndependent statistical analysis of A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich's Ataxia: primary endpoint results, effect estimate with…