ClinicalBiostats

Clinical Trials

See the methods at work.

Statistical analyses of real clinical trials: design, endpoints, results and interpretation, organized by therapeutic area and linked to the methods behind them.

6,287 trials analyzed so far

Trials that use: Mixed-effects model

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279 results

SKYLINEIndependent statistical analysis of Dose Exploration Study of GSK4532990 in. Participants With NASH or Suspected NASH: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 2Results postedn = 61NCT06104319
SOLEOIndependent statistical analysis of A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 2Results postedn = 99NCT06340958
SOLO1Complete statistical analysis of SOLO1, a randomized phase 3 trial of olaparib maintenance monotherapy versus placebo in BRCA-mutated advanced ovarian cancer following first-line platinum-based chemotherapy.Phase 3Results postedn = 450NCT01844986
SOLO3Independent statistical analysis of the SOLO3 phase 3 trial of olaparib versus single-agent chemotherapy in relapsed germline BRCA-mutated ovarian cancer, including trial design, objective response, survival endpoints, statistical methods, safety, and interpretation.Phase 3Results postedn = 266NCT02282020
SPARKIndependent statistical analysis of Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Participants With Parkinson's Disease: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 2Results postedn = 357NCT03318523
SPIRITIndependent statistical analysis of A Representational Intervention to Promote Preparation for End-of-life Decision Making: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01259011).Phase NAResults postedn = 210NCT01259011
STEP-IPFIndependent statistical analysis of STEP-IPF (NCT00517933), a randomized phase 3 trial of sildenafil versus placebo in patients with pulmonary fibrosis and pulmonary hypertension, including endpoint definitions, reported statistical analyses, interpretation, and limitations.Phase 3Results postedn = 180NCT00517933
STRIDEComplete statistical analysis of the STRIDE phase 3 trial of evidence-based tailored fall prevention versus usual care, including trial design, time-to-event analysis, longitudinal outcomes, safety, and statistical interpretation.Phase 3Results postedn = 5,451NCT02475850
STRIVEComplete statistical analysis of the STRIVE phase 3 trial of erenumab for migraine prevention, including randomized trial design, primary and secondary endpoint analyses, mixed-effects models, Cochran-Mantel-Haenszel testing, multiplicity, and safety.Phase 3Results postedn = 955NCT02456740
SuperShelfIndependent statistical analysis of A Multilevel Intervention in the Hunger Relief Network to Improve Diet Among Adults Experiencing Food Insecurity: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase NAResults postedn = 504NCT03421106
SURMOUNT-3Independent statistical analysis of the phase 3 SURMOUNT-3 trial of tirzepatide in participants with obesity or overweight after a lifestyle weight loss program, including trial design, primary endpoints, reported estimates, statistical methods,…Phase 3Results postedn = 579NCT04657016
SURMOUNT-CNIndependent statistical analysis of A Study of Tirzepatide (LY3298176) in Chinese Participants Without Type 2 Diabetes Who Have Obesity or Overweight (SURMOUNT-CN): primary endpoint results, effect estimate with confidence interval, sample-size planning…Phase 3Results postedn = 210NCT05024032
SURPASS-4Independent statistical analysis of SURPASS-4, a randomized phase 3 trial of once-weekly tirzepatide versus once-daily insulin glargine in participants with type 2 diabetes and increased cardiovascular risk.Phase 3Results postedn = 2,002NCT03730662
SURPASS-6Independent statistical analysis of A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin: primary endpoint results,…Phase 3Results postedn = 1,428NCT04537923
SURPHIndependent statistical analysis of A Study of the Response to AG-86893 in Patients With Pterygium Hyperemia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 2Results postedn = 64NCT03533244
SUSTAIN-7Independent statistical analysis of the SUSTAIN-7 phase 3 trial comparing semaglutide with dulaglutide as add-on to metformin in subjects with type 2 diabetes, including mixed-effects modeling, non-inferiority and superiority testing, confidence intervals,…Phase 3Results postedn = 1,201NCT02648204
SUSTAIN™ 2Complete statistical analysis of SUSTAIN™ 2, a randomized phase 3 trial comparing once-weekly semaglutide with once-daily sitagliptin as add-on therapy in subjects with type 2 diabetes.Phase 3Results postedn = 1,231NCT01930188
SUSTAIN™ 5Independent statistical analysis of Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes: primary…Phase 3Results postedn = 397NCT02305381
SYGMA2Complete statistical analysis of SYGMA2, a randomized phase 3 trial evaluating as-needed budesonide/formoterol versus twice-daily budesonide with as-needed terbutaline in adults and adolescents with asthma.Phase 3Results postedn = 4,215NCT02224157
T1GERIndependent statistical analysis of A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 2Results postedn = 84NCT02846545
TALCIndependent statistical analysis of Asthma Clinical Research Network (ACRN) Trial - Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (TALC):…Phase 3Results postedn = 210NCT00565266
TANGOIndependent statistical analysis of CER-001 Therapy as a Novel Approach to Treat Genetic Orphan Diseases: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 3Results postedn = 30NCT02697136
TEMPO3:4Complete statistical analysis of the TEMPO3:4 phase 3 trial of tolvaptan versus placebo in autosomal dominant polycystic kidney disease, including trial design, endpoints, mixed-effects modeling, recurrent-event analysis, ANCOVA, and reported results.Phase 3Results postedn = 1,445NCT00428948
TRANSFORM-HFComplete statistical analysis of TRANSFORM-HF, the randomized phase 3 comparison of torsemide versus furosemide for management of heart failure, including time-to-event, rehospitalization, quality-of-life, and depression analyses.Phase 3Results postedn = 2,973NCT03296813
TRFIndependent statistical analysis of Effects of a Supplement Derived From Palm Oil on Cholesterol Levels in the Blood: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 3Results postedn = 13NCT02634606
TRILOGYIndependent statistical analysis of Efficacy of Fixed Combination of Beclometasone + Formoterol + Glycopyrrolate Versus Foster® in COPD: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 3Results postedn = 1,368NCT01917331
TSMIndependent statistical analysis of Drug and Non-Drug Treatment Of Severe Migraine: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00910689).Phase 4Results postedn = 232NCT00910689
VITALIndependent statistical analysis of A Study of Dog Adoption in Veterans With Posttraumatic Stress Disorder (PTSD): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase EARLY_1Results postedn = 19NCT01729026
VitalpsIndependent statistical analysis of Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled LPS: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 1/2Results postedn = 23NCT02104505