ClinicalBiostats

Clinical Trials

See the methods at work.

Statistical analyses of real clinical trials: design, endpoints, results and interpretation, organized by therapeutic area and linked to the methods behind them.

6,287 trials analyzed so far

Trials that use: Negative binomial regression

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226 results

NEXUSIndependent statistical analysis of Dose Finding Study of Namilumab in Combination With Methotrexate in Participants With Moderate to Severe Rheumatoid Arthritis (RA): primary endpoint results, effect estimate with confidence interval, sample-size planning…Phase 2Results postedn = 108NCT02379091
NIMBLEIndependent statistical analysis of the phase 3 NIMBLE trial (NCT04718389) comparing depemokimab with mepolizumab or benralizumab in severe eosinophilic asthma, including the negative binomial exacerbation rate ratio, non-inferiority logic, ANCOVA secondary endpoints…Phase 3Results postedn = 1,717NCT04718389
NOTUSIndependent statistical analysis of the phase 3 NOTUS trial of dupilumab versus placebo in moderate to severe COPD with type 2 inflammation: negative binomial exacerbation-rate analysis, MMRM lung-function and SGRQ results, hierarchical…Phase 3Results postedn = 935NCT04456673
Operetta 2Independent statistical analysis of A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS): primary endpoint results, effect estimate with…Phase 3Results postedn = 188NCT05123703
OSKIRA-Asia-1Independent statistical analysis of Evaluation of Safety and Effectiveness of Fostamatinib Compared to Placebo in Patients in Asia With Rheumatoid Arthritis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 2Results postedn = 163NCT01569074
PEARL-IIndependent statistical analysis of A Study to Evaluate the Safety and Effect of Co-administration of ABT-450 With Ritonavir (ABT-450/r) and ABT-267 in Adults With Chronic Hepatitis C Virus Infection: primary endpoint results,…Phase 2Results postedn = 316NCT01685203
PIONEER AF-PCIIndependent statistical analysis of A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention: primary endpoint…Phase 3Results postedn = 2,124NCT01830543
PlaceboIndependent statistical analysis of Efficacy of Open Label Placebo in Children With FGIDs: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT02389998).Phase NAResults postedn = 31NCT02389998
PRINTOJDMTRIndependent statistical analysis of Five-year Actively Controlled Clinical Trial in New Onset Juvenile Dermatomyositis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00323960).Phase 3Results postedn = 139NCT00323960
PRKIndependent statistical analysis of Comparison of Cross-cylinder and Conventional Photorefractive Keratectomy(PRK) in Correcting Medium-high Astigmatism: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 3Results postedn = 50NCT00663923
PROLONG-ANG3Independent statistical analysis of A Study of LY3561774 in Participants With Mixed Dyslipidemia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05256654).Phase 2Results postedn = 205NCT05256654
PROMIS-IIAn independent statistical analysis of PROMIS-II, a phase 3 placebo-controlled trial of colistimethate sodium in non-cystic fibrosis bronchiectasis, explaining the negative binomial analysis of the annual pulmonary exacerbation rate and its rate…Phase 3Results postedn = 287NCT03460704
PRONTO-PumpIndependent statistical analysis of A Study of LY900014 and Insulin Lispro With an External Continuous Subcutaneous Insulin Infusion System in Adult Participants With Type 1 Diabetes: primary endpoint results, effect estimate with…Phase 3Results postedn = 49NCT03433677
PROPELIndependent statistical analysis of BAX 855 PK-guided Dosing: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT02585960).Phase 3Results postedn = 135NCT02585960
RAFAELOCALIndependent statistical analysis of Evaluation of the Value of Perianal Infiltration During Thermodestruction of Haemorrhoidal Disease by Radiofrequency: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 4Results postedn = 134NCT05519189
REALYSEIndependent statistical analysis of A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE): primary endpoint results, effect estimate with confidence…Phase 4Results postedn = 1,018NCT05035082
SADHART-CHFIndependent statistical analysis of Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 2/3Results postedn = 469NCT00078286
Skylight 2Independent statistical analysis of A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause - 2: primary endpoint results, effect estimate with confidence…Phase 3Results postedn = 501NCT04003142
SUPPORTIndependent statistical analysis of A Study to Evaluate the Use of Mobile-phone Based Patient Support in Patients Diagnosed With Myocardial Infarction: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase NAResults postedn = 174NCT01874262
SWITCH PROIndependent statistical analysis of A Research Study to Compare the Effect of Insulin Degludec and Insulin Glargine on Blood Sugar Levels in People With Type 2 Diabetes - the SWITCH PRO Study:…Phase 4Results postedn = 498NCT03687827
SYGMA2Complete statistical analysis of SYGMA2, a randomized phase 3 trial evaluating as-needed budesonide/formoterol versus twice-daily budesonide with as-needed terbutaline in adults and adolescents with asthma.Phase 3Results postedn = 4,215NCT02224157
TANGOIndependent statistical analysis of A Phase 3 Study of Tanezumab for Chronic Low Back Pain: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 3Results postedn = 1,832NCT02528253
TIDE-asthmaIndependent statistical analysis of Dose Ranging Study of Amlitelimab in Adult Participants With Moderate-to-severe Asthma: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 2Results postedn = 437NCT05421598
TRILOGYIndependent statistical analysis of Efficacy of Fixed Combination of Beclometasone + Formoterol + Glycopyrrolate Versus Foster® in COPD: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 3Results postedn = 1,368NCT01917331
VitalpsIndependent statistical analysis of Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled LPS: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 1/2Results postedn = 23NCT02104505
YeapleIndependent statistical analysis of Clinical Efficacy of a Toothpaste on Hypersensitivity Reduction: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01040169).Phase NAResults postedn = 79NCT01040169