Statistical methods in cardiovascular trials
The methods these trials rely on most, based on the statistical analyses posted to ClinicalTrials.gov, with the tutorial that explains each one.
Hazard ratio
ANCOVA
Cox proportional-hazards model
Non-inferiority trial design
Multiple imputation / missing data
Odds ratio
Log-rank test
t-test
All cardiovascular trials
965 results
- RE-DUAL PCIIndependent statistical analysis of RE-DUAL PCI, a randomized phase 4 trial evaluating dabigatran plus ticagrelor versus dabigatran plus clopidogrel in ACS patients with indication for NOAC undergoing PCI.
- RE-MEDYA detailed statistical analysis of the randomized phase 3 RE-MEDY trial comparing dabigatran with warfarin for secondary prevention of venous thromboembolism, including time-to-event methodology, non-inferiority analysis, bleeding outcomes, and statistical interpretation.
- REALIsM-HFIndependent statistical analysis of REALIsM-HF Pilot Study: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03507439).
- RECAD-AFIndependent statistical analysis of Regadenoson Stress-MRI to Identify Coronary Artery Disease in Atrial Fibrillation Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- RECESSComplete statistical analysis of the RECESS phase 3 trial comparing shorter- and longer-storage red blood cell units in patients undergoing cardiac surgery, including MODS, mortality, complications, and statistical methodology.
- RED-HFIndependent statistical analysis of the RED-HF phase 3 trial of darbepoetin alfa in heart failure, including trial design, time-to-event endpoints, hazard ratios, KCCQ analyses, safety, methodology, and statistical interpretation.
- Reduced-Intensity Busulfan and Fludarabine With or Without Antithymocyte Globulin Followed by Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease: Complete Statistical AnalysisIndependent statistical analysis of Reduced-Intensity Busulfan and Fludarabine With or Without Antithymocyte Globulin Followed by Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease: primary endpoint results, effect…
- REDUCEhfIndependent statistical analysis of Reducing Decompensation Events Utilizing Intracardiac Pressures in Patients With Chronic Heart Failure (HF) (REDUCEhf): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- Reducing Asymmetry During Gait Using the TPAD (Tethered Pelvic Assist Device) for Stroke Patients: Complete Statistical AnalysisIndependent statistical analysis of Reducing Asymmetry During Gait Using the TPAD (Tethered Pelvic Assist Device) for Stroke Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- Reduction in the Occurrence of Center-Involved Diabetic Macular Edema: Complete Statistical AnalysisIndependent statistical analysis of Reduction in the Occurrence of Center-Involved Diabetic Macular Edema: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00090519).
- Regadenoson Real Time Perfusion Imaging Trial-Optison: Complete Statistical AnalysisIndependent statistical analysis of Regadenoson Real Time Perfusion Imaging Trial-Optison: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01489176).
- Regional Anesthesia Following Pediatric Cardiac Surgery: Complete Statistical AnalysisIndependent statistical analysis of Regional Anesthesia Following Pediatric Cardiac Surgery: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05688670).
- REHAB-HFIndependent statistical analysis of A Trial of Rehabilitation Therapy in Older Acute Heart Failure Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- Rehabilitation in Primary Care: A Project to Maximize the Health Status of Adults With Chronic Illness: Complete Statistical AnalysisIndependent statistical analysis of Rehabilitation in Primary Care: A Project to Maximize the Health Status of Adults With Chronic Illness: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- Relative Bioavailability Study of Marketed and Lower Dose Ambrisentan in Healthy Adult Participants: Complete Statistical AnalysisIndependent statistical analysis of Relative Bioavailability Study of Marketed and Lower Dose Ambrisentan in Healthy Adult Participants: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- RELAX-AHF-2Independent statistical analysis of Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- REMATCHIndependent statistical analysis of REMATCH (NCT00000607), a randomized phase 3 trial comparing left ventricular assist device with optimal medical therapy for congestive heart failure.
- Remote Ischemic Conditioning to Enhance Resuscitation (RICE) Pilot: Complete Statistical AnalysisIndependent statistical analysis of Remote Ischemic Conditioning to Enhance Resuscitation (RICE) Pilot: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04265807).
- RENABLATE Feasibility Study CS156 (EC12-02) Study of Catheter Based Renal Denervation to Treat Resistant Hypertension: Complete Statistical AnalysisIndependent statistical analysis of RENABLATE Feasibility Study CS156 (EC12-02) Study of Catheter Based Renal Denervation to Treat Resistant Hypertension: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…
- RESCUE-Japan LIMITAn educational statistical analysis of RESCUE-Japan LIMIT, evaluating endovascular treatment for acute large vessel occlusion with large ischemic core. Includes trial design, the 90-day modified Rankin Scale endpoint, planned statistical analysis, and…
- RESISTIndependent statistical analysis of Aspirin Resistance and Percutaneous Coronary Intervention (PCI): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01103440).
- RESISTIndependent statistical analysis of Remote Ischemic Conditioning in Patients With Acute Stroke (RESIST): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03481777).
- RISE-IIPComplete statistical analysis of RISE-IIP, the randomized phase 2 trial of riociguat versus placebo in patients with symptomatic pulmonary hypertension associated with idiopathic interstitial pneumonias.
- RISE-MIndependent statistical analysis of Radiotherapy With Immunotherapy for Systemic Effect in Myeloma (RISE-M): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03634800).
- RIVER-PCIComplete statistical analysis of RIVER-PCI, a randomized phase 3 trial of ranolazine versus placebo after PCI in patients with coronary artery disease and angina pectoris, including time-to-event endpoints, Cox modeling, hazard ratios,…
- ROCKET AFIndependent statistical analysis of ROCKET AF, the randomized phase 3 trial of rivaroxaban versus warfarin for prevention of stroke and non-CNS systemic embolism in patients with non-valvular atrial fibrillation.
- ROXI-VTE IIIndependent statistical analysis of A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants: primary endpoint results, effect estimate with confidence interval, sample-size…
- RUBATOIndependent statistical analysis of Clinical Study Assessing the Efficacy and Safety of Macitentan in Fontan-palliated Subjects: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- RVD LiteIndependent statistical analysis of Lenalidomide/Bortezomib/Dexamethasone for Multiple Myeloma (MM): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01782963).
- RVDDIndependent statistical analysis of Combination Study of Revlimid®, Velcade® Dexamethasone and Doxil® (RVDD)for Newly Diagnosed Multiple Myeloma: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- SADHART-CHFIndependent statistical analysis of Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- SAFEIndependent statistical analysis of Deep Vein Thrombosis (DVT) Prevention in Total Hip Arthroplasty: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH): primary endpoint results, effect estimate with confidence interval,…
- SAPPHIREA detailed statistical analysis of the SAPPHIRE phase 3 randomized trial of carotid artery stenting in patients with carotid artery disease, including its endpoints, design, planned time-to-event analysis, and statistical interpretation.
- SBIndependent statistical analysis of An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative Recovery: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- SCASTIndependent statistical analysis of SCAST, the Scandinavian Candesartan Acute Stroke Trial, including trial design, endpoints, planned statistical methods, and interpretation.
- SCD-HeFTAn independent statistical analysis of SCD-HeFT, a randomized phase 3 trial evaluating amiodarone and implantable defibrillators in patients with heart failure and related cardiovascular conditions.
- SEQUOIA-HCMIndependent statistical analysis of Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM: primary endpoint results, effect estimate with confidence interval, sample-size…
- SHIELDIndependent statistical analysis of Phase III Study in Refractory Behcet's Disease: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00995709).
- SirolimusIndependent statistical analysis of Pharmacokinetics of Sirolimus and Tacrolimus in Liver Transplant Recipients With Tacrolimus Toxicity: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- SISCAIndependent statistical analysis of Comparison of Two Treatment Strategies in Patients With an Acute Coronary Syndrome Without ST Elevation: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…
- SMART-CHOICEIndependent statistical analysis of SMART-CHOICE, a randomized comparison of P2Y12 antagonist monotherapy versus aspirin plus P2Y12 antagonist after drug-eluting stent implantation in coronary artery disease.
- SMART-DATEIndependent statistical analysis of SMART-DATE (NCT01701453), a randomized trial evaluating 6-month duration of dual antiplatelet therapy after acute coronary syndromes.
- SmartfIREIndependent statistical analysis of A Study For Treatment Of Paroxysmal Atrial Fibrillation (PAF) With The THERMOCOOL SMARTTOUCH SF Catheter and TRUPULSE Generator: primary endpoint results, effect estimate with confidence interval, sample-size planning…
- SNOCATIndependent statistical analysis of SNOCAT, a randomized phase 2/3 trial of sodium nitrite versus placebo for out-of-hospital cardiac arrest, including primary survival results, secondary endpoints, statistical methods, and interpretation.
- SOCRATESIndependent statistical analysis of the SOCRATES phase 3 trial of ticagrelor versus acetylsalicylic acid after acute ischaemic stroke or transient ischaemic attack, including endpoint definitions, Cox and logistic regression methods, efficacy results,…
- SOLOIST-WHFIndependent statistical analysis of SOLOIST-WHF (NCT03521934), evaluating sotagliflozin versus placebo in participants with type 2 diabetes and worsening heart failure. Includes trial design, registered endpoints, Cox, ANCOVA and MMRM methodology, reported results,…
- SOLVE-TAVIAn independent statistical analysis of SOLVE-TAVI, a randomized 2×2 factorial trial comparing self-expandable versus balloon-expandable valves and general versus local anesthesia in transcatheter aortic valve implantation for aortic stenosis.
- SPACEIndependent statistical analysis of SPACE (NCT00514644), a diagnostic study evaluating carotid ultrasound and Panorama examination in patients with carotid stenoses. Includes the registered endpoint, trial design, planned prevalence analysis, and statistical interpretation.
- SPAFIndependent statistical analysis of Apixaban Drug Utilization Study In Stroke Prevention In Atrial Fibrillation (Spaf): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- SPARCLIndependent statistical analysis of the SPARCL trial evaluating atorvastatin for prevention of stroke in patients with a previous stroke. Includes trial design, endpoints, statistical methodology, and interpretation.