Infectious Disease Clinical Trials

Statistical methods in infectious disease trials

The methods these trials rely on most, based on the statistical analyses posted to ClinicalTrials.gov, with the tutorial that explains each one.

All infectious disease trials

609 results

• Adefovir Dipivoxil In Compensated Chronic Hepatitis B Patients: Complete Statistical AnalysisIndependent statistical analysis of Adefovir Dipivoxil In Compensated Chronic Hepatitis B Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00316719).Phase 3Results postedn = 105NCT00316719
• Adherence in Patients Receiving PegIntron Pen/Rebetol for Hepatitis C in Conjunction With a Patient Assistance Program (Study P04281)(COMPLETED): Complete Statistical AnalysisIndependent statistical analysis of Adherence in Patients Receiving PegIntron Pen/Rebetol for Hepatitis C in Conjunction With a Patient Assistance Program (Study P04281)(COMPLETED): primary endpoint results, effect estimate with confidence interval, sample-size planning…Phase NAResults postedn = 601NCT00704522
• Adhesive Tape Placement on Patients’ Masks in the Emergency Department Increases Compliance of Proper Face Mask Use: Complete Statistical AnalysisIndependent statistical analysis of Adhesive Tape Placement on Patients' Masks in the Emergency Department Increases Compliance of Proper Face Mask Use: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase NAResults postedn = 123NCT04812184
• ADVANCEIndependent statistical analysis of the ADVANCE phase 3 trial evaluating DTG plus TAF plus FTC versus DTG plus TDF plus FTC and EFV plus TDF plus FTC in first-line HIV-1 infection treatment.Phase 3n = 1,110NCT03122262
• AGATE-1Independent statistical analysis of A Randomized, Open-Label Study to Evaluate the Safety and Efficacy of Ombitasvir/ABT-450/Ritonavir Co-administered With Ribavirin (RBV) in Adults With Genotype 4 Chronic Hepatitis C Virus (HCV) Infection and…Phase 3Results postedn = 184NCT02265237
• AirFLO2Independent statistical analysis of AirFLO2 Treatment for Hypoxia and/or Tachypnea in Patients With COVID-19: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04649775).Phase NAResults postedn = 11NCT04649775
• Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath: Complete Statistical AnalysisIndependent statistical analysis of Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness…Phase NAResults postedn = 1,283NCT00442468
• ALCIndependent statistical analysis of Acetyl-L-Carnitine in the Treatment of Septic Shock: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00592488).Phase 1/2Results postedn = 13NCT00592488
• Algorithm for Predicting the Unfavorable Course of Sepsis in Children: Complete Statistical AnalysisIndependent statistical analysis of Algorithm for Predicting the Unfavorable Course of Sepsis in Children: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05908162).Phase NAResults postedn = 185NCT05908162
• AlloHCT From Matched Unrelated Donors in Pts w/ Advanced Hematologic Malignancies & Disorders: Complete Statistical AnalysisIndependent statistical analysis of AlloHCT From Matched Unrelated Donors in Pts w/ Advanced Hematologic Malignancies & Disorders: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…Phase NAResults postedn = 10NCT00547196
• Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia: Complete Statistical AnalysisIndependent statistical analysis of Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 3Results postedn = 561NCT01399723
• An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis: Complete Statistical AnalysisIndependent statistical analysis of An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 2Results postedn = 76NCT03557281
• An Efficacy and Safety Study of Itraconazole Sequential Therapy (Intravenous Injection Followed by Oral Solution) in Invasive Pulmonary Fungal Infections: Complete Statistical AnalysisIndependent statistical analysis of An Efficacy and Safety Study of Itraconazole Sequential Therapy (Intravenous Injection Followed by Oral Solution) in Invasive Pulmonary Fungal Infections: primary endpoint results, effect estimate with confidence interval,…Phase 4Results postedn = 71NCT01823289
• An Efficacy and Safety Study of Ravulizumab in Adult Participants With NMOSD: Complete Statistical AnalysisIndependent statistical analysis of An Efficacy and Safety Study of Ravulizumab in Adult Participants With NMOSD: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 3Results postedn = 58NCT04201262
• An Efficacy Study of Chlorhexidine Mouthwashes: Complete Statistical AnalysisIndependent statistical analysis of An Efficacy Study of Chlorhexidine Mouthwashes: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01751178).Phase 4Results postedn = 324NCT01751178
• An Efficacy, Pharmacokinetics, Safety and Tolerability Study of TMC435 as Part of a Treatment Regimen for Hepatitis C-Infected Patients: Complete Statistical AnalysisIndependent statistical analysis of An Efficacy, Pharmacokinetics, Safety and Tolerability Study of TMC435 as Part of a Treatment Regimen for Hepatitis C-Infected Patients: primary endpoint results, effect estimate with confidence interval, sample-size…Phase 3Results postedn = 457NCT01725529
• An Evaluation of Repeated Oral Doses of JNJ-64281802 Against DENV-3 Challenge: Complete Statistical AnalysisIndependent statistical analysis of An Evaluation of Repeated Oral Doses of JNJ-64281802 Against DENV-3 Challenge: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 2Results postedn = 56NCT05048875
• An Exploratory Study of Telaprevir in Treatment-Naive Participants With Chronic Genotype 4 Hepatitis C Virus Infection: Complete Statistical AnalysisIndependent statistical analysis of An Exploratory Study of Telaprevir in Treatment-Naive Participants With Chronic Genotype 4 Hepatitis C Virus Infection: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase 2Results postedn = 24NCT00580801
• An Extension Protocol for Virologically Suppressed Subjects Who Successfully Completed PRO140_CD03 Study: Complete Statistical AnalysisIndependent statistical analysis of An Extension Protocol for Virologically Suppressed Subjects Who Successfully Completed PRO140_CD03 Study: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 2/3Results postedn = 56NCT05271370
• An Observational Cohort Study in Patients With Chronic Hepatitis B Receiving Pegasys: Complete Statistical AnalysisIndependent statistical analysis of An Observational Cohort Study in Patients With Chronic Hepatitis B Receiving Pegasys: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase NAResults postedn = 1,842NCT01011738
• Anal HPV Tests in Screening for Cell Changes in the Anus in Patients With HIV: Complete Statistical AnalysisIndependent statistical analysis of Anal HPV Tests in Screening for Cell Changes in the Anus in Patients With HIV: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase NAResults postedn = 276NCT01946139
• Analytical Treatment Interruption (ATI) to Assess the Immune System’s Ability to Control HIV in Participants Who Became HIV-infected During the HVTN 703/HPTN 081 AMP Study: Complete Statistical AnalysisIndependent statistical analysis of Analytical Treatment Interruption (ATI) to Assess the Immune System's Ability to Control HIV in Participants Who Became HIV-infected During the HVTN 703/HPTN 081 AMP Study: primary endpoint results,…Phase NAResults postedn = 13NCT04860323
• ANDROMEDA-SHOCKIndependent statistical analysis of the ANDROMEDA-SHOCK randomized trial comparing peripheral perfusion versus lactate targeted fluid resuscitation in septic shock, including trial design, endpoints, statistical methodology, and interpretation.Phase NAn = 46NCT03762005
• Anidulafungin In Treatment Of Candidemia In Asian Subjects: Complete Statistical AnalysisIndependent statistical analysis of Anidulafungin In Treatment Of Candidemia In Asian Subjects: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00537329).Phase 3Results postedn = 43NCT00537329
• Annual Study to Investigate Inactivated Subunit Influenza Vaccine Due to New Virus Strains for the Southern Hemisphere 2015 Season: Complete Statistical AnalysisIndependent statistical analysis of Annual Study to Investigate Inactivated Subunit Influenza Vaccine Due to New Virus Strains for the Southern Hemisphere 2015 Season: primary endpoint results, effect estimate with confidence interval, sample-size…Phase 3Results postedn = 120NCT02381418
• ANRS PREVENIRAn independent statistical analysis of ANRS PREVENIR (NCT03113123), evaluating PrEP with Truvada for HIV prevention in Île-de-France, including the trial design, endpoint definition, planned statistical approach, and interpretation.Phase NAn = 3,257NCT03113123
• Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS): Complete Statistical AnalysisIndependent statistical analysis of Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03261830).Phase 4Results postedn = 160NCT03261830
• Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26: Complete Statistical AnalysisIndependent statistical analysis of Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 2Results postedn = 181NCT00700713
• Antibody Therapy in Treating Patients With Refractory or Relapsed Non-Hodgkin’s Lymphoma or Chronic Lymphocytic Leukemia: Complete Statistical AnalysisIndependent statistical analysis of Antibody Therapy in Treating Patients With Refractory or Relapsed Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 1Results postedn = 3NCT00014560
• APEGINIndependent statistical analysis of Evaluation of Rapid Virologic Response Among HCV Patients Treated With PegIntron and Rebetol in Brazil (Study P05427): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase NAResults postedn = 1,146NCT00724854
• APPACIndependent statistical analysis of Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01022567).Phase NAResults postedn = 530NCT01022567
• ARISEIndependent statistical analysis of the ARISE phase 3 trial evaluating Early Goal Directed Therapy in severe sepsis, including trial design, endpoints, planned analysis, statistical methodology, and interpretation.Phase 3n = 1,600NCT00975793
• ASPIREIndependent statistical analysis of the ASPIRE phase 3 trial of the dapivirine vaginal ring for prevention of HIV-1 in women, including trial design, registered endpoints, planned statistical analysis, safety, limitations, and interpretation.Phase 3Results postedn = 2,629NCT01617096
• Assess Consistency of Immunogenicity of GlaxoSmithKline Biologicals’ Pandemic Influenza Vaccine (GSK1562902A) in Adults: Complete Statistical AnalysisIndependent statistical analysis of Assess Consistency of Immunogenicity of GlaxoSmithKline Biologicals' Pandemic Influenza Vaccine (GSK1562902A) in Adults: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…Phase 3Results postedn = 1,206NCT00449670
• Assess Reacto- and Immunogenicity of Pneumococcal Conjugate Vaccine When Given as Booster or a 2 Dose Catch up Schedule: Complete Statistical AnalysisIndependent statistical analysis of Assess Reacto- and Immunogenicity of Pneumococcal Conjugate Vaccine When Given as Booster or a 2 Dose Catch up Schedule: primary endpoint results, effect estimate with confidence interval, sample-size…Phase 2Results postedn = 163NCT00513409
• Assessing PA-824 for Tuberculosis (the APT Trial): Complete Statistical AnalysisIndependent statistical analysis of Assessing PA-824 for Tuberculosis (the APT Trial): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT02256696).Phase 2Results postedn = 157NCT02256696
• Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101): Complete Statistical AnalysisIndependent statistical analysis of Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 3Results postedn = 116NCT02180165
• ASSUREIndependent statistical analysis of A Simplification Study of Unboosted Reyataz With Epzicom (ASSURE): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01102972).Phase 4Results postedn = 297NCT01102972
• ASTCIndependent statistical analysis of Antibacterial-coated Sutures at Time of Cesarean: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03386240).Phase 4Results postedn = 1,169NCT03386240
• ASTRAL-5Independent statistical analysis of Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Adults With Chronic Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV)-1 Coinfection: primary endpoint results,…Phase 3Results postedn = 107NCT02480712
• AtazanavirIndependent statistical analysis of Bioequivalence Study of Individual Atazanavir and Cobicistat Compared With Atazanavir in Fixed-dose Combination With Cobicistat: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 1Results postedn = 64NCT01837719
• Atazanavir Used in Combination With Other Anti-HIV Drugs in HIV-Infected Infants, Children, and Adolescents: Complete Statistical AnalysisIndependent statistical analysis of Atazanavir Used in Combination With Other Anti-HIV Drugs in HIV-Infected Infants, Children, and Adolescents: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 1/2Results postedn = 195NCT00006604
• Atovaquone and Azithromycin Combination for Confirmed COVID-19 Infection: Complete Statistical AnalysisIndependent statistical analysis of Atovaquone and Azithromycin Combination for Confirmed COVID-19 Infection: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04339426).Phase 2Results postedn = 3NCT04339426
• ATTACCIndependent statistical analysis of ATTACC (NCT04372589), a randomized phase 2/3 trial evaluating antithrombotic therapy with heparin in patients with COVID-19 and pneumonia, including its design, primary endpoint, planned analysis, and statistical interpretation.Phase 2/3n = 1,200NCT04372589
• AZALEAIndependent statistical analysis of the AZALEA phase 4 randomized trial of Zithromax versus placebo in asthma exacerbations, including trial design, the diary card symptom-score endpoint, planned statistical analysis, and interpretation.Phase 4n = 199NCT01444469
• AZI001Independent statistical analysis of Azithromycin in Bronchiolitis Obliterans Syndrome: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01009619).Phase 4Results postedn = 83NCT01009619
• B-cell Immunity to Influenza (SLVP017)- Year 5, 2013: Complete Statistical AnalysisIndependent statistical analysis of B-cell Immunity to Influenza (SLVP017)- Year 5, 2013: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03020537).Phase 4Results postedn = 8NCT03020537
• Bacterial Pneumonia Score (BPS) Guided Antibiotic Use in Children With Pneumonia and Pneumococcal Vaccine: Complete Statistical AnalysisIndependent statistical analysis of Bacterial Pneumonia Score (BPS) Guided Antibiotic Use in Children With Pneumonia and Pneumococcal Vaccine: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase NAResults postedn = 66NCT01875731
• Balance Function in Patients Post Corona Virus Disease 2019 (COVID-19): Complete Statistical AnalysisIndependent statistical analysis of Balance Function in Patients Post Corona Virus Disease 2019 (COVID-19): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04914364).Phase NAResults postedn = 28NCT04914364
• BARI-COVIDAn independent statistical analysis of the BARI-COVID phase 2/3 study of baricitinib in symptomatic patients infected by COVID-19, including its crossover design, ICU-transfer endpoint, planned analysis, and statistical interpretation.Phase 2/3n = 200NCT04320277

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