Infectious Disease Clinical Trials

Statistical methods in infectious disease trials

The methods these trials rely on most, based on the statistical analyses posted to ClinicalTrials.gov, with the tutorial that explains each one.

All infectious disease trials

779 results

• Clinical Study of a Single-Use, Point-of-Care Molecular Diagnostic Device for the Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) Utilizing Vaginal Swabs: Complete Statistical AnalysisIndependent statistical analysis of Clinical Study of a Single-Use, Point-of-Care Molecular Diagnostic Device for the Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) Utilizing Vaginal Swabs: primary endpoint…Phase NAResults postedn = 295NCT03596151
• Clinical Study of Efficacy and Safety of Raphamin in the Treatment of ARVI in Children 12-18 Years Old: Complete Statistical AnalysisIndependent statistical analysis of Clinical Study of Efficacy and Safety of Raphamin in the Treatment of ARVI in Children 12-18 Years Old: primary endpoint results, effect estimate with confidence interval, sample-size planning…Phase 3Results postedn = 435NCT04918771
• Clinical Study of the Immunogenicity of GSK Biologicals’ Influenza Vaccine GSK2186877A in People Aged 65 Years or Older: Complete Statistical AnalysisIndependent statistical analysis of Clinical Study of the Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in People Aged 65 Years or Older: primary endpoint results, effect estimate with confidence interval, sample-size planning…Phase 3Results postedn = 192NCT00765076
• Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of Otomycosis: Complete Statistical AnalysisIndependent statistical analysis of Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of Otomycosis: primary endpoint results, effect estimate with confidence interval,…Phase 3Results postedn = 190NCT01993823
• Clinical Study to Evaluate the Safety, Immunogenicity and Efficacy of Investigational Flu Vaccine Compared to Approved Flu Vaccine in Children.: Complete Statistical AnalysisIndependent statistical analysis of Clinical Study to Evaluate the Safety, Immunogenicity and Efficacy of Investigational Flu Vaccine Compared to Approved Flu Vaccine in Children.: primary endpoint results, effect estimate with confidence interval,…Phase 3Results postedn = 10,644NCT01964989
• Clinical Study to Evaluate the Therapeutic Equivalence of Ketoconazole Cream 2% in the Treatment of Tinea Pedis: Complete Statistical AnalysisIndependent statistical analysis of Clinical Study to Evaluate the Therapeutic Equivalence of Ketoconazole Cream 2% in the Treatment of Tinea Pedis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 3Results postedn = 831NCT03824912
• Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia: Complete Statistical AnalysisIndependent statistical analysis of Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 1/2Results postedn = 93NCT01471782
• Clinical Trial of CNS-targeted HAART (CIT2): Complete Statistical AnalysisIndependent statistical analysis of Clinical Trial of CNS-targeted HAART (CIT2): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00624195).Phase 2/3Results postedn = 59NCT00624195
• Clinical Trial to Evaluate the Efficacy, Pharmacokinetics (PK) Interactions and Safety of Dolutegravir Plus 2 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in HIV-1-Infected Solid Organ Transplant Patients: Complete Statistical AnalysisIndependent statistical analysis of Clinical Trial to Evaluate the Efficacy, Pharmacokinetics (PK) Interactions and Safety of Dolutegravir Plus 2 Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in HIV-1-Infected Solid Organ Transplant Patients: primary endpoint…Phase 4Results postedn = 19NCT03360682
• Code SepsisIndependent statistical analysis of Effects of Code Sepsis Implementation on Emergency Department (ED) Sepsis Care: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase NAResults postedn = 180,402NCT04148989
• Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria: Complete Statistical AnalysisIndependent statistical analysis of Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00351273).Phase 3Results postedn = 42NCT00351273
• Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Burkitt’s Lymphoma or Leukemia: Complete Statistical AnalysisIndependent statistical analysis of Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Burkitt's Lymphoma or Leukemia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 2Results postedn = 23NCT00133991
• Communities Fighting COVID Return to School: Complete Statistical AnalysisIndependent statistical analysis of Communities Fighting COVID Return to School: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05150860).Phase NAResults postedn = 852NCT05150860
• Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections: Complete Statistical AnalysisIndependent statistical analysis of Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 3Results postedn = 680NCT00423657
• Comparative Trial of Entecavir Versus Adefovir in the Treatment of Chronic Hepatitis B Infection: Complete Statistical AnalysisIndependent statistical analysis of Comparative Trial of Entecavir Versus Adefovir in the Treatment of Chronic Hepatitis B Infection: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 3Results postedn = 69NCT00096785
• Comparison of Fluconazole vs Voriconazole to Treat Fungal Infections for Blood and Marrow Transplants (BMT CTN 0101): Complete Statistical AnalysisIndependent statistical analysis of Comparison of Fluconazole vs Voriconazole to Treat Fungal Infections for Blood and Marrow Transplants (BMT CTN 0101): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 3Results postedn = 600NCT00075803
• Comparison of Seasonal Allergic Rhinitis Treatment With 2 Antihistamines Used in Combination With Intranasal Corticosteroid: Complete Statistical AnalysisIndependent statistical analysis of Comparison of Seasonal Allergic Rhinitis Treatment With 2 Antihistamines Used in Combination With Intranasal Corticosteroid: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase 4Results postedn = 150NCT00845195
• Comparison of Telemedicine to Usual Care for HCV Management for Methadone-maintained Individuals: Complete Statistical AnalysisIndependent statistical analysis of Comparison of Telemedicine to Usual Care for HCV Management for Methadone-maintained Individuals: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase NAResults postedn = 602NCT02933970
• Compression Treatment Effects on Complications and Healing of Achilles Tendon Rupture: Complete Statistical AnalysisIndependent statistical analysis of Compression Treatment Effects on Complications and Healing of Achilles Tendon Rupture: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase NAResults postedn = 150NCT01317160
• Computer-Assisted Self-Interviews and Health Screening in the Pediatric Emergency Department: Complete Statistical AnalysisIndependent statistical analysis of Computer-Assisted Self-Interviews and Health Screening in the Pediatric Emergency Department: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01708317).Phase NAResults postedn = 801NCT01708317
• Concomitant Use of Gardasil (V501, Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine) With Combined Diptheria, Tetanus, Pertussis and Poliomyelitis Vaccine in Adolescents (V501-024)(COMPLETED): Complete Statistical AnalysisIndependent statistical analysis of Concomitant Use of Gardasil (V501, Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine) With Combined Diptheria, Tetanus, Pertussis and Poliomyelitis Vaccine in Adolescents (V501-024)(COMPLETED): primary endpoint results,…Phase 3Results postedn = 843NCT00337428
• CONDA-YAPAIndependent statistical analysis of Home Assessment and Initiation of Antiretroviral Therapy for HIV in Malawi: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase NAResults postedn = 16,660NCT01414413
• Consistency Lots Vaccine Study (V260-009): Complete Statistical AnalysisIndependent statistical analysis of Consistency Lots Vaccine Study (V260-009): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00092456).Phase 3Results postedn = 793NCT00092456
• CONTAINIndependent statistical analysis of Inhaled Ciclesonide for Outpatients With COVID19: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04435795).Phase 2/3Results postedn = 215NCT04435795
• Convalescent Plasma vs. Standard Plasma for COVID-19: Complete Statistical AnalysisIndependent statistical analysis of Convalescent Plasma vs. Standard Plasma for COVID-19: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04344535).Phase 1/2Results postedn = 82NCT04344535
• Conversion to Envarsus Post Kidney Transplant Protects Against BK Infection: Complete Statistical AnalysisIndependent statistical analysis of Conversion to Envarsus Post Kidney Transplant Protects Against BK Infection: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03762473).Phase 2Results postedn = 89NCT03762473
• COPDGeneIndependent statistical analysis and educational interpretation of the COPDGene study, evaluating genetic factors associated with chronic obstructive pulmonary disease, emphysema, bronchitis, and related baseline measurements.n = 10,718NCT00608764
• COPPSIndependent statistical analysis of COVID-19 Outpatient Pragmatic Platform Study (COPPS) - Acebilustat Sub-Protocol: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04662060).Phase 2Results postedn = 120NCT04662060
• COPPSIndependent statistical analysis of COVID-19 Outpatient Pragmatic Platform Study (COPPS) - Camostat Sub-Protocol: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04662073).Phase 2Results postedn = 2NCT04662073
• CORONAIndependent statistical analysis of the randomized phase 3 CORONA trial of levilimab versus placebo in patients with severe COVID-19, including the primary endpoint, trial design, planned statistical analysis, and interpretation.Phase 3n = 206NCT04397562
• COV-BARRIERComplete statistical analysis of the COV-BARRIER phase 3 trial of baricitinib plus standard of care versus placebo plus standard of care in participants with COVID-19, including trial design, endpoints, statistical methodology, reported…Phase 3Results postedn = 1,525NCT04421027
• COV002Independent statistical analysis of COV002 (NCT04400838), a randomized phase 2/3 trial investigating ChAdOx1 nCoV-19 for prevention of COVID-19 in adults, including its design, endpoints, planned statistical methods, and interpretation.Phase 2/3n = 10,811NCT04400838
• COV003Independent statistical analysis and educational interpretation of COV003, a phase 3 randomized study of ChAdOx1 nCoV-19 for prevention of COVID-19 disease confirmed with PCR.Phase 3n = 10,300NCT04536051
• COVACTAIndependent statistical analysis of the randomized phase 3 COVACTA trial evaluating tocilizumab versus placebo in patients with severe COVID-19 pneumonia, including endpoint definitions, reported treatment effects, confidence intervals, p-values, and statistical methodology.Phase 3Results postedn = 452NCT04320615
• COVACTAIndependent statistical analysis of A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase 3Results postedn = 452NCT04320615
• COVENANTIndependent statistical analysis of HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 3Results postedn = 535NCT03284866
• COVID SAFE 2Independent statistical analysis of COVID-19 Screening Program: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05216627).Phase NAResults postedn = 61NCT05216627
• COVID-19Complete statistical analysis of the randomized phase 3 COLCORONA trial of colchicine versus placebo in ambulatory patients with Corona Virus Infection, including trial design, endpoints, statistical methods, reported results, safety, and interpretation.Phase 3Results postedn = 4,506NCT04322682
• COVID-19 MP Biomedicals Rapid SARS-CoV-2 Antigen Test Usability: Complete Statistical AnalysisIndependent statistical analysis of COVID-19 MP Biomedicals Rapid SARS-CoV-2 Antigen Test Usability: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05584189).Phase NAResults postedn = 99NCT05584189
• COVID-19 PEPComplete statistical analysis of the randomized phase 3 COVID-19 PEP trial of hydroxychloroquine versus placebo for post-exposure prophylaxis and preemptive therapy for SARS-CoV-2.Phase 3Results postedn = 1,312NCT04308668
• COVID-19 PrEP HCW HCQ Study: Complete Statistical AnalysisIndependent statistical analysis of COVID-19 PrEP HCW HCQ Study: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04354870).Phase 2Results postedn = 130NCT04354870
• COVID-19 Project ECHO in Nursing Homes: Complete Statistical AnalysisIndependent statistical analysis of COVID-19 Project ECHO in Nursing Homes: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04499391).Phase NAResults postedn = 136NCT04499391
• COVID-19 Vaccine Hesitancy Counseling Intervention for Pharmacists: A Stepped-Wedge Trial: Complete Statistical AnalysisIndependent statistical analysis of COVID-19 Vaccine Hesitancy Counseling Intervention for Pharmacists: A Stepped-Wedge Trial: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT06547814).Phase NAResults postedn = 20NCT06547814
• COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE): Complete Statistical AnalysisIndependent statistical analysis of COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04595773).Phase NAResults postedn = 48NCT04595773
• COViNOXIndependent statistical analysis of A Study to Assess Pulsed Inhaled Nitric Oxide vs Placebo in Subjects With Mild or Moderate COVID-19: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 3Results postedn = 191NCT04421508
• CoVPN 3006A detailed statistical analysis of CoVPN 3006, a randomized phase 3 crossover study evaluating Moderna COVID-19 Vaccine against SARS-CoV-2 infection and COVID-19 disease through the Month 4 study visit.Phase 3Results postedn = 1,923NCT04811664
• Cranberry Effect on Urinary Tract Infections: Complete Statistical AnalysisIndependent statistical analysis of Cranberry Effect on Urinary Tract Infections: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT02996981).Phase NAResults postedn = 167NCT02996981
• CROSSIndependent statistical analysis of Cesarean Trial of Staples vs. Sutures: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01211600).Phase NAResults postedn = 746NCT01211600
• Cross-vaccination Study of GSK Biologicals’ Herpes Zoster Subunit (HZ/su) Vaccine (GSK 1437173A) in Subjects Who Previously Received Placebo in ZOSTER-006 (NCT01165177) and ZOSTER-022 (NCT01165229) Studies.: Complete Statistical AnalysisIndependent statistical analysis of Cross-vaccination Study of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK 1437173A) in Subjects Who Previously Received Placebo in ZOSTER-006 (NCT01165177) and ZOSTER-022 (NCT01165229) Studies.: primary endpoint results,…Phase 3Results postedn = 8,687NCT02690207
• CROWN CORONAIndependent statistical analysis of the randomized phase 3 CROWN CORONA trial evaluating M-M-R II vaccine versus placebo for prevention of symptomatic COVID-19, including Bayesian logistic regression, risk differences, confidence intervals, p-values, and…Phase 3Results postedn = 3,411NCT04333732

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