Infectious Disease Clinical Trials

Statistical methods in infectious disease trials

The methods these trials rely on most, based on the statistical analyses posted to ClinicalTrials.gov, with the tutorial that explains each one.

All infectious disease trials

903 results

• Early Antibiotics After Aspiration in ICU Patients: Complete Statistical AnalysisIndependent statistical analysis of Early Antibiotics After Aspiration in ICU Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05079620).Phase 4Results postedn = 5NCT05079620
• Early Insulin and Development of ARDS: Complete Statistical AnalysisIndependent statistical analysis of Early Insulin and Development of ARDS: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00605696).Phase 2Results postedn = 18NCT00605696
• EARNESTIndependent statistical analysis of the EARNEST phase 3 trial evaluating second-line HIV therapy strategies, including trial design, endpoints, statistical methodology, and interpretation.Phase 3n = 1,277NCT00988039
• EBL06Independent statistical analysis and educational interpretation of the randomized phase 1 EBL06 trial evaluating a short-interval prime-boost Ebola vaccination strategy.Phase 1Results postedn = 40NCT02485912
• EBR/GZR for HCV-1b Patients Receiving Hemodialysis: Complete Statistical AnalysisIndependent statistical analysis of EBR/GZR for HCV-1b Patients Receiving Hemodialysis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03420300).Phase 4Results postedn = 40NCT03420300
• EDUCATEIndependent statistical analysis of Clinical Trial to Evaluate the Immunogenicity of an Adjuvanted Influenza Vaccine Among HCP: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…Phase 3Results postedn = 192NCT06054269
• Efavirenz (EFV) Intensification: Complete Statistical AnalysisIndependent statistical analysis of Efavirenz (EFV) Intensification: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT07193875).Phase 4Results postedn = 9NCT07193875
• Effect of Dalcetrapib in Patients With Confirmed Mild to Moderate COVID-19: Complete Statistical AnalysisIndependent statistical analysis of Effect of Dalcetrapib in Patients With Confirmed Mild to Moderate COVID-19: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 2Results postedn = 227NCT04676867
• Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination: Complete Statistical AnalysisIndependent statistical analysis of Effect of Dose, Safety, Tolerability of a New Smallpox Vaccine in Adults Without Previous Smallpox Vaccination: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase 2Results postedn = 353NCT00053495
• Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics: Complete Statistical AnalysisIndependent statistical analysis of Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 4Results postedn = 43NCT01386970
• Effect of Insulin Resistance on the Safety and Efficacy of Pegylated Interferon and Ribavirin Treatment in HCV (Study P05562): Complete Statistical AnalysisIndependent statistical analysis of Effect of Insulin Resistance on the Safety and Efficacy of Pegylated Interferon and Ribavirin Treatment in HCV (Study P05562): primary endpoint results, effect estimate with confidence interval, sample-size…Phase NAResults postedn = 250NCT00705224
• Effect of Losartan on Airway Mucociliary Dysfunction in Patients With COPD and Chronic Bronchitis: Complete Statistical AnalysisIndependent statistical analysis of Effect of Losartan on Airway Mucociliary Dysfunction in Patients With COPD and Chronic Bronchitis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase 4Results postedn = 31NCT02416102
• Effect of Probiotic Lactobacilli (Lacidofil Cap®) for the Prevention of Antibiotic-Associated Diarrhea: Complete Statistical AnalysisIndependent statistical analysis of Effect of Probiotic Lactobacilli (Lacidofil Cap®) for the Prevention of Antibiotic-Associated Diarrhea: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase NAResults postedn = 214NCT01058356
• Effect of Raltegravir on Endothelial Function in HIV-Infected Patients: Complete Statistical AnalysisIndependent statistical analysis of Effect of Raltegravir on Endothelial Function in HIV-Infected Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00843713).Phase 4Results postedn = 56NCT00843713
• Effect of Risk Factors Likely to Influence Immuno of Combined Hepatitis A & B Vacc vs Monovalent Hepatitis A & B Vacc: Complete Statistical AnalysisIndependent statistical analysis of Effect of Risk Factors Likely to Influence Immuno of Combined Hepatitis A & B Vacc vs Monovalent Hepatitis A & B Vacc: primary endpoint results, effect estimate with…Phase 4Results postedn = 596NCT00289731
• Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa: Complete Statistical AnalysisIndependent statistical analysis of Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 2Results postedn = 21NCT02805595
• Effectiveness of Armodafinil for Treating Fatigue in Adults With HIV/AIDS: Complete Statistical AnalysisIndependent statistical analysis of Effectiveness of Armodafinil for Treating Fatigue in Adults With HIV/AIDS: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00737204).Phase 4Results postedn = 70NCT00737204
• Effectiveness of Modafinil for Treating Fatigue in Adults With HIV/AIDS: Complete Statistical AnalysisIndependent statistical analysis of Effectiveness of Modafinil for Treating Fatigue in Adults With HIV/AIDS: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00118378).Phase 4Results postedn = 115NCT00118378
• Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis: Complete Statistical AnalysisIndependent statistical analysis of Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03705793).Phase 4Results postedn = 53NCT03705793
• Effectiveness of Monovalent Rotavirus Vaccine (RV1): Complete Statistical AnalysisIndependent statistical analysis of Effectiveness of Monovalent Rotavirus Vaccine (RV1): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01871038).Phase NAResults postedn = 362NCT01871038
• Effects of a Common Cold Treatment on Cognitive Function: Complete Statistical AnalysisIndependent statistical analysis of Effects of a Common Cold Treatment on Cognitive Function: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01466348).Phase 4Results postedn = 72NCT01466348
• Effects of Chronic Viral Infection on Immune Response to Zoster Vaccination: Complete Statistical AnalysisIndependent statistical analysis of Effects of Chronic Viral Infection on Immune Response to Zoster Vaccination: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase NAResults postedn = 14NCT02590068
• Effects of Doravirine (MK-1439) on Methadone Pharmacokinetics in Methadone-Maintained Participants (MK-1439-045): Complete Statistical AnalysisIndependent statistical analysis of Effects of Doravirine (MK-1439) on Methadone Pharmacokinetics in Methadone-Maintained Participants (MK-1439-045): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase 1Results postedn = 14NCT02715700
• Effects of Ledipasvir/Sofosbuvir on the Pharmacokinetics and Renal Safety of Tenofovir Alafenamide (TAF): Complete Statistical AnalysisIndependent statistical analysis of Effects of Ledipasvir/Sofosbuvir on the Pharmacokinetics and Renal Safety of Tenofovir Alafenamide (TAF): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…Phase 4Results postedn = 10NCT03126370
• Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy: Complete Statistical AnalysisIndependent statistical analysis of Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…Phase NAResults postedn = 251NCT01479478
• Effects of Sodium Pyruvate Nasal Spray in COVID-19 Long Haulers.: Complete Statistical AnalysisIndependent statistical analysis of Effects of Sodium Pyruvate Nasal Spray in COVID-19 Long Haulers.: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04871815).Phase 2/3Results postedn = 22NCT04871815
• Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 2Results postedn = 20NCT02644525
• Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 3Results postedn = 944NCT04123405
• Efficacy and Safety of BIO-K + CL1285 in Prevention of Antibiotic-associated Diarrhea in Hospitalized Adult Patients: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of BIO-K + CL1285 in Prevention of Antibiotic-associated Diarrhea in Hospitalized Adult Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase 3Results postedn = 472NCT00328263
• Efficacy and Safety of Ceftaroline Versus Linezolid in Subjects With Complicated Skin and Skin Structure Infections: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Ceftaroline Versus Linezolid in Subjects With Complicated Skin and Skin Structure Infections: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase 2Results postedn = 150NCT00633152
• Efficacy and Safety of Elbasvir (MK-8742) + Grazoprevir (MK-5172) in Treatment-Naïve/Treatment-Experienced (TN/TE) French Participants With Hepatitis C Virus (HCV) Genotype 4 (GT4) Infection (MK-5172-096): Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Elbasvir (MK-8742) + Grazoprevir (MK-5172) in Treatment-Naïve/Treatment-Experienced (TN/TE) French Participants With Hepatitis C Virus (HCV) Genotype 4 (GT4) Infection (MK-5172-096): primary endpoint results, effect…Phase 4Results postedn = 117NCT03111108
• Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes: primary endpoint results, effect estimate with confidence interval, sample-size…Phase 3Results postedn = 1,179NCT00306787
• Efficacy and Safety of MP-424, Peginterferon Alfa-2b and Ribavirin in Chronic Hepatitis C Who Have Not Achieved an Undetectable HCV RNA Level With Previous Interferon Based Therapy: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of MP-424, Peginterferon Alfa-2b and Ribavirin in Chronic Hepatitis C Who Have Not Achieved an Undetectable HCV RNA Level With Previous Interferon Based Therapy: primary…Phase 3Results postedn = 32NCT00781274
• Efficacy and Safety of Nemonoxacin vs Levofloxacin in Adult Patients With Community-Acquired Pneumonia: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Nemonoxacin vs Levofloxacin in Adult Patients With Community-Acquired Pneumonia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…Phase 3Results postedn = 342NCT03551210
• Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis (VANISH 303): Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis (VANISH 303): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 3Results postedn = 376NCT03734991
• Efficacy and Safety of Polyoxidonium, Nasal and Sublingual Spray, 6 mg/ml in Children Aged 1-12 Years With ARI: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Polyoxidonium, Nasal and Sublingual Spray, 6 mg/ml in Children Aged 1-12 Years With ARI: primary endpoint results, effect estimate with confidence interval, sample-size planning…Phase 3Results postedn = 172NCT03840135
• Efficacy and Safety of Ravidasvir + Danoprevir/r 12-week Oral Therapy in Treatment-Naive Non Cirrhotic G1 CHC Taiwan: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Ravidasvir + Danoprevir/r 12-week Oral Therapy in Treatment-Naive Non Cirrhotic G1 CHC Taiwan: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 2Results postedn = 38NCT03020095
• Efficacy and Safety of Resatorvid in Patients With Sepsis-induced Cardiovascular and Respiratory Failure: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Resatorvid in Patients With Sepsis-induced Cardiovascular and Respiratory Failure: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…Phase 3Results postedn = 18NCT00633477
• Efficacy and Safety of Sofosbuvir Plus Ribavirin in Chronic Genotype 1, 2 and 3 Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Co-infected Adults: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Sofosbuvir Plus Ribavirin in Chronic Genotype 1, 2 and 3 Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Co-infected Adults: primary endpoint results,…Phase 3Results postedn = 224NCT01667731
• Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Participants With Chronic HCV: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Participants With Chronic HCV: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…Phase 3Results postedn = 375NCT02671500
• Efficacy And Safety Of Sofosbuvir/Velpatasvir Fixed Dose Combination With Ribavirin in Chronic HCV Infected Adults Who Participated in a Prior Gilead Sponsored HCV Treatment Study: Complete Statistical AnalysisIndependent statistical analysis of Efficacy And Safety Of Sofosbuvir/Velpatasvir Fixed Dose Combination With Ribavirin in Chronic HCV Infected Adults Who Participated in a Prior Gilead Sponsored HCV Treatment Study: primary endpoint results,…Phase 2Results postedn = 69NCT02300103
• Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis): Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 2/3Results postedn = 382NCT04432376
• Efficacy and Safety Study of Moxidectin in Adults With Scabies: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety Study of Moxidectin in Adults With Scabies: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05875441).Phase 2Results postedn = 200NCT05875441
• Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria: Complete Statistical AnalysisIndependent statistical analysis of Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria: primary endpoint results, effect estimate with confidence…Phase 3Results postedn = 150NCT02802501
• Efficacy of a Plant-derived Quadrivalent Virus-like Particle (VLP) Vaccine in the Elderly: Complete Statistical AnalysisIndependent statistical analysis of Efficacy of a Plant-derived Quadrivalent Virus-like Particle (VLP) Vaccine in the Elderly: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 3Results postedn = 12,794NCT03739112
• Efficacy of an Abstinence-Only HIV Risk-Reduction Intervention for Young African-American Adolescents: Complete Statistical AnalysisIndependent statistical analysis of Efficacy of an Abstinence-Only HIV Risk-Reduction Intervention for Young African-American Adolescents: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…Phase NAResults postedn = 662NCT00640653
• Efficacy of an Antibacterial Toothpaste and Patients’ Satisfaction: Complete Statistical AnalysisIndependent statistical analysis of Efficacy of an Antibacterial Toothpaste and Patients' Satisfaction: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05569850).Phase NAResults postedn = 100NCT05569850
• Efficacy of Anaferon for Children in the Treatment of Influenza and Acute Respiratory Viral Infections in Children: Complete Statistical AnalysisIndependent statistical analysis of Efficacy of Anaferon for Children in the Treatment of Influenza and Acute Respiratory Viral Infections in Children: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…Phase 4Results postedn = 569NCT02072174
• Efficacy of Betalactam Antibiotics in Prolonged Infusion Compared to Intermittent in Pediatric Patients With Sepsis: Complete Statistical AnalysisIndependent statistical analysis of Efficacy of Betalactam Antibiotics in Prolonged Infusion Compared to Intermittent in Pediatric Patients With Sepsis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…Phase NAResults postedn = 426NCT03019965
• Efficacy of Ciprofloxacin for the Treatment of Uncomplicated Urinary Tract Infection (uUTI): Complete Statistical AnalysisIndependent statistical analysis of Efficacy of Ciprofloxacin for the Treatment of Uncomplicated Urinary Tract Infection (uUTI): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…Phase 4Results postedn = 250NCT03366207

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