Statistical methods in neurology trials
The methods these trials rely on most, based on the statistical analyses posted to ClinicalTrials.gov, with the tutorial that explains each one.
ANCOVA
Mixed-effects model
Odds ratio
MMRM (mixed model for repeated measures)
Multiple imputation / missing data
Hazard ratio
Cochran-Mantel-Haenszel test
Non-inferiority trial design
All neurology trials
1,213 results
- Normobaric Hyperoxia for Intracerebral Hemorrhage: Complete Statistical AnalysisIndependent statistical analysis of Normobaric Hyperoxia for Intracerebral Hemorrhage: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04144868).
- NOVA2Independent statistical analysis of Inhaled Nitric Oxide and Neuroprotection in Premature Infants: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00515281).
- Novel Cognitive Treatment Targets for Epidiolex in Sturge- Weber Syndrome: Complete Statistical AnalysisIndependent statistical analysis of Novel Cognitive Treatment Targets for Epidiolex in Sturge- Weber Syndrome: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04447846).
- Novel Insight Into Migraine Pathophysiolgy and Galcanezumab Mechanisms of Action: Complete Statistical AnalysisIndependent statistical analysis of Novel Insight Into Migraine Pathophysiolgy and Galcanezumab Mechanisms of Action: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04271202).
- Novel Management of Airway Protection in Parkinson’s Disease: A Clinical Trial: Complete Statistical AnalysisIndependent statistical analysis of Novel Management of Airway Protection in Parkinson's Disease: A Clinical Trial: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- Novel Portable Diagnostic Device for Automatic Detection of Relative Afferent Pupillary Defect: Complete Statistical AnalysisIndependent statistical analysis of Novel Portable Diagnostic Device for Automatic Detection of Relative Afferent Pupillary Defect: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries: Complete Statistical AnalysisIndependent statistical analysis of NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- OARS-PilotIndependent statistical analysis of Opioid Analgesic Reduction Study (OARS) - Pilot: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05283499).
- OASIS(CM)Independent statistical analysis of Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic Migraine: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- Obesity, Sleep Apnea, and Insulin Resistance: Complete Statistical AnalysisIndependent statistical analysis of Obesity, Sleep Apnea, and Insulin Resistance: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT02192684).
- Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma: Complete Statistical AnalysisIndependent statistical analysis of Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- Obstructive Sleep Apnea in World Trade Center Responders: Complete Statistical AnalysisIndependent statistical analysis of Obstructive Sleep Apnea in World Trade Center Responders: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01753999).
- OLE-IEDATIndependent statistical analysis of Extension Treatment Using EryDex System in Patients With AT Who Participated in the ATTeST-IEDAT-02-2015 Study: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…
- Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder: Complete Statistical AnalysisIndependent statistical analysis of Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00511810).
- One-Day Life Skills Workshop for Veterans With TBI, Pain and Psychopathology: Complete Statistical AnalysisIndependent statistical analysis of One-Day Life Skills Workshop for Veterans With TBI, Pain and Psychopathology: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- Online Caregiver Psychoeducation and Support for Alzheimer’s: Complete Statistical AnalysisIndependent statistical analysis of Online Caregiver Psychoeducation and Support for Alzheimer's: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00416078).
- Open Label Safety and Efficacy Study of Levetiracetam in Patients With Epilepsy: Complete Statistical AnalysisIndependent statistical analysis of Open Label Safety and Efficacy Study of Levetiracetam in Patients With Epilepsy: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- Open Label Safety/Immunogenicity Study of MYOBLOC (Neurobloc; Botulinum Toxin Type B) in Patients With Cervical Dystonia: Complete Statistical AnalysisIndependent statistical analysis of Open Label Safety/Immunogenicity Study of MYOBLOC (Neurobloc; Botulinum Toxin Type B) in Patients With Cervical Dystonia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- Open Label Study To Evaluate The Long-Term Safety Profiles Of Caduet In Japanese Patients: Complete Statistical AnalysisIndependent statistical analysis of Open Label Study To Evaluate The Long-Term Safety Profiles Of Caduet In Japanese Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD): Complete Statistical AnalysisIndependent statistical analysis of Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD): primary endpoint results, effect estimate with confidence interval, sample-size planning…
- Open-label Extension Study to Evaluate the Safety of Long-term Twice-monthly Administration of Somavaratan in Adult Growth Hormone Deficiency (AGHD): Complete Statistical AnalysisIndependent statistical analysis of Open-label Extension Study to Evaluate the Safety of Long-term Twice-monthly Administration of Somavaratan in Adult Growth Hormone Deficiency (AGHD): primary endpoint results, effect estimate with confidence interval, sample-size…
- Open-label Long-term Safety Study of AT1001 (Migalastat Hydrochloride) in Participants With Fabry Disease Who Have Completed a Previous AT1001 Study: Complete Statistical AnalysisIndependent statistical analysis of Open-label Long-term Safety Study of AT1001 (Migalastat Hydrochloride) in Participants With Fabry Disease Who Have Completed a Previous AT1001 Study: primary endpoint results, effect estimate with confidence interval,…
- Open-Label Safety and Tolerability of Oxymorphone IR and ER in Opioid Tolerant Pediatric Subjects: Complete Statistical AnalysisIndependent statistical analysis of Open-Label Safety and Tolerability of Oxymorphone IR and ER in Opioid Tolerant Pediatric Subjects: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.: Complete Statistical AnalysisIndependent statistical analysis of Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- Open-label Study of Levetiracetam Intravenous Infusion in Children (1 Month-4 Years Old) With Epilepsy: Complete Statistical AnalysisIndependent statistical analysis of Open-label Study of Levetiracetam Intravenous Infusion in Children (1 Month-4 Years Old) With Epilepsy: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- Open-label, Randomized Study in a Pediatric Population in a JEV (Japanese Encephalitis Virus)-Endemic Country: Complete Statistical AnalysisIndependent statistical analysis of Open-label, Randomized Study in a Pediatric Population in a JEV (Japanese Encephalitis Virus)-Endemic Country: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- Open-label, Randomized, 2-way Crossover, Monocentric, Controlled Study to Evaluate the Effect on Daily PHE Fluctuation of PKU GOLIKE Versus SoC in Patients With PKU.: Complete Statistical AnalysisIndependent statistical analysis of Open-label, Randomized, 2-way Crossover, Monocentric, Controlled Study to Evaluate the Effect on Daily PHE Fluctuation of PKU GOLIKE Versus SoC in Patients With PKU.: primary endpoint results, effect…
- Open, Prosp, Rand. Invest. Evaluating Pain With Mepitel One vs.Bridal Veil and Staples on Split Thickness Skin Grafts: Complete Statistical AnalysisIndependent statistical analysis of Open, Prosp, Rand. Invest. Evaluating Pain With Mepitel One vs.Bridal Veil and Staples on Split Thickness Skin Grafts: primary endpoint results, effect estimate with confidence interval, sample-size planning…
- Operetta 2Independent statistical analysis of A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS): primary endpoint results, effect estimate with…
- Ophthalmologic Safety Study of Pramipexole Immediate Release (IR) Versus Ropinirole in Early Parkinson’s Disease (PD) Patients: Complete Statistical AnalysisIndependent statistical analysis of Ophthalmologic Safety Study of Pramipexole Immediate Release (IR) Versus Ropinirole in Early Parkinson's Disease (PD) Patients: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- Optic-to-Audio Device in a Pediatric Cohort With CLN3-related Conditions or Low Vision: Complete Statistical AnalysisIndependent statistical analysis of Optic-to-Audio Device in a Pediatric Cohort With CLN3-related Conditions or Low Vision: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- Optiflow THRIVE for Delivery of Oxygen to Patients During Total Intravenous Anesthesia While Undergoing Radiology Procedures: Complete Statistical AnalysisIndependent statistical analysis of Optiflow THRIVE for Delivery of Oxygen to Patients During Total Intravenous Anesthesia While Undergoing Radiology Procedures: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- OPTIMASIndependent statistical analysis of OPTIMAS (NCT03759938), a randomized trial evaluating early versus standard initiation of direct oral anticoagulant treatment after acute ischaemic stroke in patients with atrial fibrillation.
- OPTIMISEIndependent statistical analysis of Occipital Nerve Stimulation (ONS) for Migraine: OPTIMISE: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01775735).
- Optimizing Care for Patients With Dementia: Complete Statistical AnalysisIndependent statistical analysis of Optimizing Care for Patients With Dementia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03442322).
- Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease: Complete Statistical AnalysisIndependent statistical analysis of Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- OPTIMUMIndependent statistical analysis of Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT02425644).
- Oral Pregabalin as Preemptive Analgesia in Abdominal Hysterectomy: Complete Statistical AnalysisIndependent statistical analysis of Oral Pregabalin as Preemptive Analgesia in Abdominal Hysterectomy: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04495374).
- Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma: Complete Statistical AnalysisIndependent statistical analysis of Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT00301418).
- ORATORIOIndependent statistical analysis of ORATORIO (NCT05974839), evaluating the effect of ocrelizumab on cortical lesion number accumulation in patients with primary progressive multiple sclerosis over 5 years.
- ORIGINALComplete statistical analysis of the ORIGINAL phase 3 trial comparing tenecteplase with alteplase in Chinese patients with stroke, including trial design, non-inferiority methodology, efficacy, safety, and interpretation.
- Orthostatic Hypotension Treatment on Rehab Unit: Complete Statistical AnalysisIndependent statistical analysis of Orthostatic Hypotension Treatment on Rehab Unit: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT01030874).
- Osia CPT Code Study: Complete Statistical AnalysisIndependent statistical analysis of Osia CPT Code Study: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT04320407).
- OTBB2Independent statistical analysis of Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Infants: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- OTO-313 in Subjects With Subjective Tinnitus: Complete Statistical AnalysisIndependent statistical analysis of OTO-313 in Subjects With Subjective Tinnitus: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03918109).
- Outpatient and Home Advanced Rehabilitation Therapeutics Using Jintronix Virtual Reality Telerehabilitation System: Complete Statistical AnalysisIndependent statistical analysis of Outpatient and Home Advanced Rehabilitation Therapeutics Using Jintronix Virtual Reality Telerehabilitation System: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- OXT-PWSIndependent statistical analysis of Oxytocin vs. Placebo for the Treatment Hyperphagia in Children and Adolescents With Prader-Willi Syndrome: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- Oxygen Monitoring of Patients After Surgery on the Hospital General Care Floor: Complete Statistical AnalysisIndependent statistical analysis of Oxygen Monitoring of Patients After Surgery on the Hospital General Care Floor: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- PACEIndependent statistical analysis of Effect of Physical ACtivity in Fingolimod Treated patiEnts (PACE) With Relapsing-remitting Multiple Sclerosis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- Pain Control Following Sinus Surgery: Complete Statistical AnalysisIndependent statistical analysis of Pain Control Following Sinus Surgery: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03783702).