Statistical methods in neurology trials
The methods these trials rely on most, based on the statistical analyses posted to ClinicalTrials.gov, with the tutorial that explains each one.
ANCOVA
Mixed-effects model
Odds ratio
MMRM (mixed model for repeated measures)
Multiple imputation / missing data
Hazard ratio
Cochran-Mantel-Haenszel test
Non-inferiority trial design
All neurology trials
816 results
- A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression: Complete Statistical AnalysisIndependent statistical analysis of A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis: Complete Statistical AnalysisIndependent statistical analysis of A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer’s Disease: Complete Statistical AnalysisIndependent statistical analysis of A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety,…
- A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis: Complete Statistical AnalysisIndependent statistical analysis of A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…
- A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia: Complete Statistical AnalysisIndependent statistical analysis of A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- A Study of Sativex® for Relief of Peripheral Neuropathic Pain Associated With Allodynia.: Complete Statistical AnalysisIndependent statistical analysis of A Study of Sativex® for Relief of Peripheral Neuropathic Pain Associated With Allodynia.: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on…
- A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome: Complete Statistical AnalysisIndependent statistical analysis of A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome: primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome: Complete Statistical AnalysisIndependent statistical analysis of A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study Of The Analgesic (Pain-Relief) Effects Of Tanezumab In Adult Patients With Diabetic Peripheral Neuropathy: Complete Statistical AnalysisIndependent statistical analysis of A Study Of The Analgesic (Pain-Relief) Effects Of Tanezumab In Adult Patients With Diabetic Peripheral Neuropathy: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS: Complete Statistical AnalysisIndependent statistical analysis of A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- A Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD): Complete Statistical AnalysisIndependent statistical analysis of A Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD): primary endpoint results, effect estimate…
- A Study Of The Safety And Efficacy Of Levetiracetam (Keppra®) (Ucb L059) In Children With Epilepsy: Complete Statistical AnalysisIndependent statistical analysis of A Study Of The Safety And Efficacy Of Levetiracetam (Keppra®) (Ucb L059) In Children With Epilepsy: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(MK-0773-005): Complete Statistical AnalysisIndependent statistical analysis of A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(MK-0773-005): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…
- A Study of the Safety and Efficacy of Pimavanserin (ACP-103) in Patients With Parkinson’s Disease Psychosis: Complete Statistical AnalysisIndependent statistical analysis of A Study of the Safety and Efficacy of Pimavanserin (ACP-103) in Patients With Parkinson's Disease Psychosis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy: Complete Statistical AnalysisIndependent statistical analysis of A Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- A Study of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-006): Complete Statistical AnalysisIndependent statistical analysis of A Study of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-006): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov…
- A Study of V950 in People With Alzheimer Disease (V950-001 AM7): Complete Statistical AnalysisIndependent statistical analysis of A Study of V950 in People With Alzheimer Disease (V950-001 AM7): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results…
- A Study of VI-0521 for the Treatment of Obstructive Sleep Apnea / Hypopnea Syndrome in Obese Adults: Complete Statistical AnalysisIndependent statistical analysis of A Study of VI-0521 for the Treatment of Obstructive Sleep Apnea / Hypopnea Syndrome in Obese Adults: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…
- A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome: Complete Statistical AnalysisIndependent statistical analysis of A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome: primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Assess the Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Extension Study): Complete Statistical AnalysisIndependent statistical analysis of A Study to Assess the Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Extension Study): primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Assess the Efficacy and Safety of Brivaracetam as Treatment for Increased Seizure Activity in an Epilepsy Monitoring Unit Setting: Complete Statistical AnalysisIndependent statistical analysis of A Study to Assess the Efficacy and Safety of Brivaracetam as Treatment for Increased Seizure Activity in an Epilepsy Monitoring Unit Setting: primary endpoint results, effect estimate with…
- A Study to Assess the Long-term Safety and Efficacy of ATB200/AT2221 in Adult Subjects With Late-Onset Pompe Disease (LOPD): Complete Statistical AnalysisIndependent statistical analysis of A Study to Assess the Long-term Safety and Efficacy of ATB200/AT2221 in Adult Subjects With Late-Onset Pompe Disease (LOPD): primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Assess the Long-term Safety and Efficacy of Erenumab (AMG 334) in Chronic Migraine Prevention.: Complete Statistical AnalysisIndependent statistical analysis of A Study to Assess the Long-term Safety and Efficacy of Erenumab (AMG 334) in Chronic Migraine Prevention.: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…
- A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET): Complete Statistical AnalysisIndependent statistical analysis of A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET): primary endpoint results, effect estimate with…
- A Study to Characterize Diclofenac’s Plasma and Knee Exposure After Application of Diclofenac Gel to the Knee of Subjects With Osteoarthritis That Have a Scheduled Arthroplasty: Complete Statistical AnalysisIndependent statistical analysis of A Study to Characterize Diclofenac's Plasma and Knee Exposure After Application of Diclofenac Gel to the Knee of Subjects With Osteoarthritis That Have a Scheduled Arthroplasty: primary endpoint…
- A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Users When ALO-02 Capsules Are Crushed and Snorted: Complete Statistical AnalysisIndependent statistical analysis of A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Users When ALO-02 Capsules Are Crushed and Snorted: primary endpoint results, effect estimate with…
- A Study to Determine the Maintenance of Effect After Long-term Treatment of Sativex® in Subjects With Neuropathic Pain: Complete Statistical AnalysisIndependent statistical analysis of A Study to Determine the Maintenance of Effect After Long-term Treatment of Sativex® in Subjects With Neuropathic Pain: primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionectomy: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionectomy: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Evaluate Pharyngeal Immunity to Poliovirus Type-2: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate Pharyngeal Immunity to Poliovirus Type-2: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT05677256).
- A Study to Evaluate Safety and Efficacy of Elagolix in Participants With Endometriosis With Associated Moderate to Severe Pain: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate Safety and Efficacy of Elagolix in Participants With Endometriosis With Associated Moderate to Severe Pain: primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Evaluate SAGE-217 in Participants With Parkinson’s Disease: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate SAGE-217 in Participants With Parkinson's Disease: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based on ClinicalTrials.gov results (NCT03000569).
- A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington’s Disease (HD): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…
- A Study to Evaluate the Effects of Ocrelizumab on Immune Responses In Participants With Relapsing Forms of Multiple Sclerosis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Effects of Ocrelizumab on Immune Responses In Participants With Relapsing Forms of Multiple Sclerosis: primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Evaluate the Efficacy and Safety of Safinamide, as add-on Therapy, in Idiopathic Chinese Parkinson’s Disease (PD) Patients With Motor Fluctuations Treated With Stable Doses of Levodopa: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Efficacy and Safety of Safinamide, as add-on Therapy, in Idiopathic Chinese Parkinson's Disease (PD) Patients With Motor Fluctuations Treated With Stable Doses of…
- A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdominal Hysterectomy: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdominal Hysterectomy: primary endpoint results, effect estimate with confidence interval,…
- A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine (0462-087): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine (0462-087): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Evaluate the Efficacy of Sativex in Relieving Symptoms of Spasticity Due to Multiple Sclerosis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Efficacy of Sativex in Relieving Symptoms of Spasticity Due to Multiple Sclerosis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration,…
- A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Participants With Giant Cell Arteritis (GCA).: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Participants With Giant Cell Arteritis (GCA).: primary endpoint results, effect estimate with confidence interval,…
- A Study to Evaluate the Safe and Effective Use of a Zilucoplan Auto-injector by Study Participants With Generalized Myasthenia Gravis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safe and Effective Use of a Zilucoplan Auto-injector by Study Participants With Generalized Myasthenia Gravis: primary endpoint results, effect estimate with confidence interval,…
- A Study to Evaluate the Safety and Efficacy of Satralizumab in Participants With Neuromyelitis Optica Spectrum Disorder (NMOSD): Complete Statistical AnalysisIndependent statistical analysis of A Study to Evaluate the Safety and Efficacy of Satralizumab in Participants With Neuromyelitis Optica Spectrum Disorder (NMOSD): primary endpoint results, effect estimate with confidence interval, sample-size planning…
- A Study to Explore the Safety And Tolerability of Doses of E2007 Up to a Maximum of 8 mg In Patients With Parkinson’s Disease Who Experience End-of-Dose Wearing Off Motor Fluctuations: Complete Statistical AnalysisIndependent statistical analysis of A Study to Explore the Safety And Tolerability of Doses of E2007 Up to a Maximum of 8 mg In Patients With Parkinson's Disease Who Experience End-of-Dose Wearing…
- A Study to Investigate the Analgesic Efficacy of AZD2423 Compared With Placebo After 28 Days Treatment in Patients With Painful Diabetic Polyneuropathy: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Analgesic Efficacy of AZD2423 Compared With Placebo After 28 Days Treatment in Patients With Painful Diabetic Polyneuropathy: primary endpoint results, effect estimate with…
- A Study to Investigate the Efficacy and Safety of GSK3196165 in Inflammatory Hand Osteoarthritis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Efficacy and Safety of GSK3196165 in Inflammatory Hand Osteoarthritis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…
- A Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis: primary endpoint results, effect estimate with confidence interval, sample-size…
- A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich’s Ataxia: Complete Statistical AnalysisIndependent statistical analysis of A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich's Ataxia: primary endpoint results, effect estimate with…
- A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo: Complete Statistical AnalysisIndependent statistical analysis of A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After…
- A Study to Look at the Efficacy and Safety of Keppra® Extended Release Formulation – XR: Complete Statistical AnalysisIndependent statistical analysis of A Study to Look at the Efficacy and Safety of Keppra® Extended Release Formulation - XR: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Test Efficacy and Safety of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis: Complete Statistical AnalysisIndependent statistical analysis of A Study to Test Efficacy and Safety of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis: primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and…
- A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Participants 6 to 17 Years of Age: Complete Statistical AnalysisIndependent statistical analysis of A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Participants 6 to 17 Years of Age: primary endpoint results, effect estimate with confidence interval,…
- A Study to Test if Fremanezumab Reduces Headache in Participants With Posttraumatic Headache (PTH): Complete Statistical AnalysisIndependent statistical analysis of A Study to Test if Fremanezumab Reduces Headache in Participants With Posttraumatic Headache (PTH): primary endpoint results, effect estimate with confidence interval, sample-size planning illustration, and safety, based…