Statistical methods in ophthalmology trials
The methods these trials rely on most, based on the statistical analyses posted to ClinicalTrials.gov, with the tutorial that explains each one.
ANCOVA
Multiple imputation / missing data
Cochran-Mantel-Haenszel test
Non-inferiority trial design
Risk difference
MMRM (mixed model for repeated measures)
Odds ratio
ANOVA
All ophthalmology trials
4 results
- COAT TrialAn independent statistical analysis of the COAT Trial evaluating cyclosporine ophthalmic solution for dry eye. Includes trial design, endpoint methodology, statistical interpretation, and limitations.
- GATSBYA complete statistical analysis and educational interpretation of the GATSBY phase 1/2 trial of gevokizumab for scleritis, including its single-group design, ordinal scleral inflammation endpoint, planned statistical approach, and reported safety.
- N-MOmentumComplete statistical analysis of the N-MOmentum randomized phase 2/3 trial of inebilizumab versus placebo in neuromyelitis optica spectrum disorders, including time-to-event, logistic regression, ANCOVA, and hospitalization analyses.
- VISIONARY-MSIndependent statistical analysis of VISIONARY-MS (NCT03536559), a randomized phase 2 trial evaluating CNM-Au8 for remyelination failure in chronic optic neuropathy in multiple sclerosis.