Common Pharmacokinetic Modeling Mistakes
A practical guide to common pharmacokinetic modeling mistakes, including inappropriate structural models, poor sampling, overparameterization, incorrect error models, identifiability problems, and misinterpretation of PK parameters.
Clearance and Volume of Distribution Explained
A practical introduction to clearance and volume of distribution in pharmacokinetics, including their definitions, equations, relationship to concentration and exposure, half-life, dosing, and worked examples.
Absorption Rate Constants and Flip-Flop Kinetics
Learn how absorption rate constants describe drug input after extravascular dosing, how ka relates to absorption half-life and Tmax, and how flip-flop kinetics can make the observed terminal phase reflect absorption rather than elimination.