Topic: Exposure Metrics: AUC, Cmax and Partial AUC

Worked AUC and Partial-AUC Calculation

Units and Time-Scale Checks for Exposure Metrics

Why AUC Is Less Peak-Sensitive Than Cmax

Switching Between Linear and Log Trapezoids

Tmax as a Sampling-Resolution Statistic

Selecting the Terminal-Phase Slope

Partial AUC Sensitivity to Window Placement

Peak Misspecification Under Sparse Sampling

Profile Crossing: Equal Total AUC, Different Timing

Observed Cmax and the Sampling Grid