Topic: Exposure Metrics: AUC, Cmax and Partial AUC

Observed Cmax and the Sampling Grid

Interpolating Concentrations at Partial-AUC Boundaries

Extrapolating AUC to Infinity

Flat Peaks and Tied Tmax Values

Dose-Normalized AUC and Cmax

Exposure Metrics Under Different Sampling Schedules

Diagnosing an Unreliable AUC Extrapolation

Diagnostic Workshop: Choosing an Exposure Metric

Deriving the Linear Trapezoidal Rule

Deriving the Log Trapezoidal Rule