Topic: In Vitro to In Vivo Extrapolation of Metabolism

Scaling Hepatocyte Intrinsic Clearance to the Whole Liver

Relative Activity and Inter-System Extrapolation Factors

Propagating Uncertainty in IVIVE Scaling Factors

Plasma Binding Corrections in Unbound Clearance Prediction

Measuring Unbound Fraction in Microsomal Incubations

Microsomal Protein per Gram of Liver as a Scaling Factor

Liver Mass in Whole-Organ Clearance Scaling

Interpreting Low-Turnover Assays Near the Quantification Limit

Enzyme Stability as a Source of IVIVE Bias

Diagnosing IVIVE Bias with Scaled Clearance Comparisons