Topic: In Vitro to In Vivo Extrapolation of Metabolism

Worked Example of Cross-Species Microsomal IVIVE

Worked Example of End-to-End Human IVIVE

Why Microsomal IVIVE Can Underpredict In Vivo Clearance

Why In Vitro Scaling Can Overpredict In Vivo Clearance

The IVIVE Chain from Assay Turnover to Human Clearance

Species-Specific Scaling Factors for Liver Preparations

Separating Metabolism from Nonspecific Substrate Loss

Scaling Recombinant Enzyme Turnover to Liver Clearance

Scaling S9 Fraction Metabolism to the Whole Liver

Scaling Metabolite Formation Rates for IVIVE