Topic: Model-Based Endpoint and Sample Size Planning

Worked Sample-Size Planning for a Longitudinal Endpoint

Treatment-Effect Heterogeneity and Subgroup-Specific Precision

Time-to-Event Endpoints: Event Targets and Sample Size

Sensitivity Analysis for Uncertain Sample-Size Inputs

Repeated-Measure Correlation and Effective Sample Size

Multiplicity Across Endpoints, Doses, and Assessment Times

Missing Data and Intercurrent Events in Endpoint Power

Fisher Information Methods for Model-Based Sample Size

Diagnosing Fragile Endpoint and Sample-Size Plans

Deriving Treatment Contrasts From Longitudinal Mixed Models