Topic: Model-Based Endpoint and Sample Size Planning

Composite and Hierarchical Endpoints With Unequal Component Effects

Count and Recurrent-Event Endpoints Under Overdispersion

Covariate Adjustment and Precision Gains in Sample-Size Calculations

Choosing Assessment Times for Longitudinal Endpoints

Baseline and Natural-History Models for Precision Planning

Binary Responder Endpoints and Threshold Selection

Biomarker Endpoint Planning Under Surrogate Uncertainty

Aligning Estimands With Model-Based Endpoint Contrasts