UGT-Mediated Metabolism in PBPK
Learn how UDP-glucuronosyltransferase-mediated metabolism is represented in physiologically based pharmacokinetic models, including UGT reaction phenotyping, enzyme kinetics, intrinsic clearance, IVIVE, hepatic and intestinal metabolism, and drug-drug interaction prediction.
Time-Dependent Inhibition in PBPK
Learn how time-dependent inhibition is represented in physiologically based pharmacokinetic models, including reversible inhibition, mechanism-based inactivation, KI, kinact, enzyme turnover, PBPK implementation, and clinical drug-drug interaction prediction.
Renal Clearance in PBPK
Learn how renal clearance is represented in physiologically based pharmacokinetic models, including glomerular filtration, active tubular secretion, tubular reabsorption, renal blood flow, and mechanistic prediction of renal drug elimination.
Physiological Systems in PBPK Models
Learn how physiological systems are represented in physiologically based pharmacokinetic models, including organ volumes, blood flows, tissue partitioning, hepatic and renal elimination, gastrointestinal physiology, and population variability.
PBPK vs. Population PK Models
A practical introduction to physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models, including their assumptions, parameters, data requirements, applications, strengths, limitations, and how they can be used together.
PBPK for Transporter-Mediated Drug Interactions
Learn how physiologically based pharmacokinetic models describe transporter-mediated drug interactions, including uptake and efflux transporters, inhibition, induction, intestinal and hepatic transport, and mechanistic DDI prediction.
PBPK for Pregnancy and Lactation
Learn how physiologically based pharmacokinetic models can represent pregnancy-related changes in maternal drug disposition, placental transfer, fetal exposure, lactation, breast milk concentrations, and infant exposure.
PBPK for Pediatric Populations
Learn how physiologically based pharmacokinetic models are adapted for pediatric populations using age-dependent physiology, organ growth, body composition, enzyme and transporter ontogeny, renal maturation, and mechanistic dose prediction.
PBPK for Formulation and Bioequivalence
Learn how physiologically based pharmacokinetic models connect drug properties, formulation, dissolution, gastrointestinal physiology, and systemic exposure to support formulation development and bioequivalence assessment.
PBPK for Food-Drug Interactions
Learn how physiologically based pharmacokinetic models describe and predict food-drug interactions by integrating drug properties, formulation, gastrointestinal physiology, absorption, metabolism, and systemic disposition.