PBPK for CYP-Mediated Drug Interactions
Learn how physiologically based pharmacokinetic models describe CYP-mediated drug-drug interactions, including CYP inhibition, induction, fraction metabolized, hepatic and intestinal metabolism, perpetrator and victim drugs, and prediction of clinical DDI magnitude.
PBPK Model Verification and Qualification
A practical guide to PBPK model verification and qualification, including structural verification, mass balance, numerical accuracy, predictive performance, qualification for intended use, external evaluation, uncertainty, and regulatory reporting.
Organ Compartments in PBPK
Learn how organs and tissues are represented as compartments in physiologically based pharmacokinetic models, including blood flow, tissue volume, partition coefficients, mass-balance equations, metabolism, and model interpretation.
Nonlinear Clearance in PBPK
Learn how nonlinear clearance arises in physiologically based pharmacokinetic models, including saturable metabolism, active transport, Michaelis-Menten elimination, organ extraction, and dose-dependent exposure.
Mechanistic Drug-Drug Interaction Modeling
Learn how mechanistic drug-drug interaction models use enzyme inhibition, induction, transporters, unbound concentrations, and PBPK models to predict changes in drug exposure and support clinical DDI assessment.
Mechanistic Absorption Models in PBPK
Learn how mechanistic absorption models represent dissolution, solubility, permeability, intestinal transit, precipitation, and other processes that determine oral drug absorption in physiologically based pharmacokinetic models.
Introduction to Physiologically Based Pharmacokinetic Modeling
An introduction to physiologically based pharmacokinetic modeling, including physiological systems, drug-specific properties, organ compartments, absorption, distribution, metabolism, excretion, IVIVE, model development, qualification, and applications in drug development.
Intestinal Permeability in PBPK
Learn how intestinal permeability is represented in physiologically based pharmacokinetic models, including passive diffusion, effective permeability, transporter effects, intestinal metabolism, and the connection between permeability and oral bioavailability.
Hepatic Clearance in PBPK
Learn how hepatic clearance is represented in physiologically based pharmacokinetic models, including hepatic blood flow, extraction ratio, intrinsic clearance, protein binding, the well-stirred liver model, IVIVE, transporters, and hepatic impairment.
Gastrointestinal Transit in PBPK
Learn how gastrointestinal transit, gastric emptying, and intestinal transit are represented in physiologically based pharmacokinetic models and how transit affects dissolution, absorption, exposure, food effects, and oral drug pharmacokinetics.