First-Pass Metabolism in PBPK
Learn how first-pass metabolism is represented in physiologically based pharmacokinetic models, including intestinal and hepatic extraction, bioavailability, hepatic blood flow, enzyme clearance, and the well-stirred liver model.
Enzyme Induction in PBPK
Learn how enzyme induction is represented in physiologically based pharmacokinetic models, including nuclear receptor activation, enzyme turnover, delayed onset and offset, CYP induction, in vitro data, and prediction of drug-drug interactions.
Drug Transporters in PBPK Models
Learn how drug transporters are incorporated into physiologically based pharmacokinetic models, including uptake and efflux transport, intestinal, hepatic, and renal transporters, transporter-mediated drug-drug interactions, and PBPK model implementation.
Drug Metabolizing Enzymes in PBPK
Learn how drug metabolizing enzymes are represented in physiologically based pharmacokinetic models, including CYPs, UGTs, enzyme abundance, intrinsic clearance, induction, inhibition, and scaling from in vitro data to human PK.
Drug Dissolution and Solubility in PBPK
Learn how drug solubility and dissolution influence oral absorption in physiologically based pharmacokinetic models, including pH-dependent solubility, particle size, precipitation, supersaturation, and formulation effects.
Cytochrome P450 Modeling
Learn how cytochrome P450 enzymes are represented in pharmacokinetic and PBPK models, including intrinsic clearance, enzyme abundance, inhibition, induction, genotype effects, and drug-drug interactions.
Blood Flow and Tissue Distribution in PBPK
Learn how blood flow, tissue perfusion, tissue partitioning, and permeability determine drug distribution in physiologically based pharmacokinetic models.
Anatomy of a PBPK Model
Learn the anatomy of a physiologically based pharmacokinetic (PBPK) model, including organs, blood flows, tissue volumes, partition coefficients, clearance, drug properties, equations, model inputs, parameterization, validation, and simulation.
Active Renal Secretion in PBPK
Learn how active renal secretion is represented in physiologically based pharmacokinetic models, including renal transporters, tubular secretion, intrinsic clearance, transporter inhibition, drug-drug interactions, and mechanistic renal clearance.