Topic: Pediatric Ontogeny and Scaling

Worked Example: Scaling Clearance From Adults to Neonates

Worked Example: Simulating Exposure Across Pediatric Age Bands

Transporter Ontogeny for Hepatic Uptake and Efflux

UGT and FMO Ontogeny in Pediatric PBPK

Separating Body-Size Scaling From Ontogeny

Scaling Organ Mass and Blood Flow During Growth

Scaling In Vitro Transporter Abundance to Pediatric Tissues

Representing Pediatric Growth in Whole-Body PBPK Models

Pubertal Changes in Enzyme and Transporter Activity

Predicting Tissue Partitioning Across Pediatric Ages