QSP Models of Viral Infection
An introduction to quantitative systems pharmacology models of viral infection, including target cells, infected cells, viral production and clearance, immune responses, antiviral mechanisms, model calibration, and simulation.
QSP Models of T-Cell Activation
Learn how quantitative systems pharmacology models represent T-cell activation through TCR signaling, co-stimulation, intracellular signaling, cytokine production, proliferation, and immune-cell interactions.
QSP Models of Resistance Mechanisms
A practical introduction to quantitative systems pharmacology models of resistance mechanisms, including target alterations, pathway reactivation, drug efflux, immune escape, tumor heterogeneity, and how mechanistic models can represent treatment resistance over time.
QSP Models of Renal Physiology
Learn how quantitative systems pharmacology models represent renal physiology, including glomerular filtration, tubular reabsorption and secretion, renal clearance, fluid and electrolyte regulation, acid-base homeostasis, and kidney-mediated drug disposition.
QSP Models of Organ Crosstalk
Learn how quantitative systems pharmacology models represent organ crosstalk, inter-organ signaling, circulating mediators, feedback loops, and drug effects across integrated physiological systems.
QSP Models of Neurotransmitter Systems
Learn how quantitative systems pharmacology models represent neurotransmitter synthesis, release, reuptake, metabolism, receptor binding, autoregulation, and downstream signaling in CNS drug development.
QSP Models of Neurodegenerative Disease
Learn how quantitative systems pharmacology models represent neurodegenerative disease biology, including neuronal loss, protein aggregation, neuroinflammation, neurotransmitter systems, disease progression, biomarkers, treatment effects, and translational predictions.
QSP Models of Lipid Metabolism
Learn how quantitative systems pharmacology models represent lipid metabolism, lipoprotein transport, cholesterol homeostasis, triglyceride dynamics, drug mechanisms, and metabolic disease.
QSP Models of Inflammatory Disease
Learn how quantitative systems pharmacology models represent inflammatory disease mechanisms, cytokine networks, immune-cell interactions, drug mechanisms, biomarkers, virtual patients, and treatment response.
QSP Models of Immune Checkpoint Inhibitors
Learn how quantitative systems pharmacology models describe immune checkpoint inhibitors, including target engagement, T-cell activation, tumor-immune dynamics, pharmacokinetics, pharmacodynamics, combination therapy, and model-based prediction.