Topic: Sensitivity Analysis and Parameter Reduction

Worked Workshop on PBPK Parameter Reduction

Why One-At-a-Time Sensitivity Can Mislead

Time- and Endpoint-Dependent Sensitivity Rankings

Singular-Value Analysis of Sensitivity Matrices

Sobol Indices for Global Sensitivity

Sensitivities of Time Courses and Summary Endpoints

Sensitivity Across Doses and Physiological Scenarios

Sensitivity-Based Identifiability Diagnostics

Second-Order Local Sensitivity and Interactions

Reparameterizing Informative Parameter Combinations