Topic: Simulation-Based Design Assurance

Stress-Testing Missingness and Nonadherence

Stress-Testing Model Misspecification

Simulating One Adaptive Trial Replicate

Simultaneous Precision Across Multiple Scenarios

Selection Accuracy and Treatment Allocation

Sensitivity Analysis for Nuisance Parameters

Sensitivity to Recruitment and Accrual Patterns

Scenario Weighting and Average Performance

Replication Counts for Target Precision

Reporting Simulation Assumptions and Results